Chemistry and Biology of the Streptogramin A Antibiotics

Fahim Ahmed; William A. Donaldson

doi:10.2174/157019307780599315

ISSN: 1570-193X
E-ISSN: 1875-6298

Chemistry and Biology of the Streptogramin A Antibiotics
Authors: Fahim Ahmed¹ and William A. Donaldson²
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¹ Department of Chemistry,Marquette University, P. O. Box 1881, Milwaukee, WI 53201-1881 USA. ² Department of Chemistry,Marquette University, P. O. Box 1881, Milwaukee, WI 53201-1881 USA.
Source: Mini-Reviews in Organic Chemistry, Volume 4, Issue 2, May 2007, p. 159 - 181
DOI: https://doi.org/10.2174/157019307780599315
- Available online: 01 May 2007

Abstract

The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene, oxazole, amide and ester functionality. The chemistry and biology of these valuable antimicrobial agents is covered.

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2007-05-01

2025-05-25

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Article Type: Research Article

Keyword(s): Antibiotics; biosynthetic origin; mode of action; synthetic studies; total synthesis

Chemistry and Biology of the Streptogramin A Antibiotics

Abstract

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