Mini-Reviews in Organic Chemistry - Volume 17, Issue 6, 2020

Pyroglutamic acid is one of the privileged asymmetric precursors for the synthesis of a variety of molecules such as Angiotensin-Converting Enzyme (ACE) inhibitors, angiotensin II receptor subtypes (AT-1 receptor antagonists), as well as bioactive natural products. Starting with primary reports in 1980’s, last almost four decades has witnessed a rapid overgrowth of publications using pyroglutamic acid as a preferred asy Read More

The flavonoids by their natural properties and their diverse applications are a group of compounds whose study of origin, characteristics and applications has been dedicated to extensive research. For the organic synthesis of chalcones, due to their interest as precursor molecules of different compounds, several pathways have been developed and reported in numerous works. Analyses on the effect of some of these Read More

Pyrazolotriazolopyrimidines are an important class of nitrogen-containing heterocycles that can act as a charismatic target and exhibit diverse pharmacological activities. These compounds have received much attention because they are an attractive scaffold for the preparation of adenosine receptor antagonists. Herein, we focus on an overview of the synthesis of these compounds with the aim of assisting in the di Read More

PABA (p-aminobenzoic acid) is an important substrate for the synthesis of various biological scaffolds. Its pharmacological significance is apparent form the drugs like folic acid and benzocaine, which are used for certain biological disorders. Although, it is not a vitamin but still it is referred as a member of vitamin B. The deficiency of PABA leads to several disorders like erratic white areas of skin, grey hair, fatigue, depression an Read More

In recent decades, enzymes have been the target of considerable research, development, and innovation. This paper presents an up-to-date overview of the technological application of lipases in the pharmaceutical industry. Lipases have been used in a variety of ways in the pharmaceutical industry, both for obtaining bioactive molecules to overcome limitations in the formulation of medicines and in drug desi Read More

The present review has highlighted the chemistry of pyrimido[1,2-a]pyrimidine compounds as one of the most important classes of heterocyclic systems. The main sections include: (1) The synthesis of pyrimido[1,2-a]pyrimidines, (2) reactivity of the substituents attached to the carbon and nitrogen atoms of the ring and (3) biological applications. A discussion demonstrated that the proposed mechanisms of unexpected synt Read More

Due to its inherent advantages such as easy recovery and reuse of the catalysts/ reagents, and environmentally friendly nature, the heterogeneous system has gain popularity in the realm of organic synthesis. In recent years, several chemically or biologically potent molecules are achieved through heterogeneous synthesis strategies. By recalling some of the classical fundamentals of the heterogeneous system in important Read More

Flavonoids are widely distributed in the plant kingdom and possess a variety of biological activities, such as anti-oxidant, anti-inflammatory, and anti-viral activities. Due to the structural diversity and biological activity, flavonoid derivatives isolated from Verbenaceae family have received a lot of attention by the research scholars. In this paper, a total of 150 natural flavonoids isolated from Verbenaceae and their bioactivities w Read More