Mini-Reviews in Organic Chemistry - Volume 14, Issue 2, 2017

Background: The canthin-4-ones are a small, yet underexplored class of natural products from Apocynaceae plants. Efficient synthetic approaches are required for exploring this class of natural products for drug discovery. Objective: In this review, the synthetic approaches towards these alkaloids, as well as synthetic analogues are summarized comprehensively. Further, the applications of canthin-4-ones as building blocks Read More

This paper describes the mechanism of nitrogen and phosphorus removal by activated sludge process, and introduces several conventional nitrogen and phosphorus bioremoval processes, namely sequencing batch reactor (SBR), anaerobic-anoxic-aerobic (AAO), oxidation ditch, and bio-doubling process (BDP). Many improved technologies were invented to compensate for the defects of conventional activated sludge pro Read More

Alkynes and cumulenes share the common feature of at least one sp-hybridized carbon atom in the molecule. This leads to the molecules having relatively high energy in the thermodynamic sense, but also having high stability in the kinetic sense. Enediynes, enyne-cumulenes and yne-diynes all undergo pericyclic reactions resulting in cycloaromatization to dehydrobenzenes and related products. In this review, the history, me Read More

Recently Fe3O4@silica sulfuric acid as an efficient nanomagnetically recyclable solid acid catalyst has been synthesized and used in organic transformations. Magnetic nanoparticles were synthesized by simple co-precipitation of FeCl2.4H2O and FeCl3.6H2O in ammonia solution. Then, after addition of tetraethyl orthosilicate in ammonia solution, silica was formed on the surface of magnetite nanoparticles. Finally, the ca Read More

Recent developments of functionalization of C(sp3)-H bonds adjacent to oxygen of alcohols under metal-free conditions are summarized here. Alcohols are one of the most common and useful chemicals, so the direct functionalization of C(sp3)-H bonds adjacent to oxygen of alcohols is a promising direction in organic synthesis.

The use of microwave irradiation in organic chemistry and, in particular in 1,3-dipolar cycloaddition has recently gained much attention and great progress has been accomplished in this area in the last years. In general, the modern synthetic chemistry is benefited by microwave irradiation that provides an environmentally benign approach, reduced reaction times and a few formation of byproducts, increasing the yield. This revi Read More

Barbituric acid (pyrimidine-2,4,6(1H,3H,5H)-trione) as odourless white crystals has been prepared in 1864. Due to the acidity of the CH2 group, the pyrimidine ring of barbituric acid could be stabilized via the resonance delocalization, which led it to show potential donor-acceptor properties of the heteroatoms in the molecule. Barbituric acid and its derivatives are versatile moieties in many compounds which possess interesting utili Read More