Mini-Reviews in Organic Chemistry - Volume 14, Issue 6, 2017

Background: Quaternary α-amino acids with a tetrasubstituted carbon stereocenter have a variety of biological activities. Due to the steric hindrance of the quaternary carbon centers, highly efficient asymmetric catalytic synthesis is greatly challenging. Objective: In this paper, with a focus on the asymmetric formation of chemical bonds in reactions, the asymmetric catalytic synthesis of quaternary α-amino acids in re Read More

Background: Nucleoside triphosphates (NTPs) synthesis has recently been an area of searching for new methods and possible applications in biochemistry and medicine. However, we still lack a universal tool to synthesize NTPs easily and efficiently. For years, the most popular method has been the “one-pot, three step” conception by Ludwig with its subsequent improvements which used Yoshikawa's et al. monophosphoryla Read More

Background: Benzodiazepines (BDZs) are the bicyclic heterocyclic compounds in which benzene ring is fused to seven membered ring containing two nitrogen atoms. There are different types of BDZs such as 1, 2-benzodiazepines, 1, 3-benzodiazepines, 1, 4-benzodiazepines, 1, 5-benzodiazepines- 2, 3-benzodiazepines possess anxiolytic, anticonvulsant, antipsychotics, muscle relaxant and antimicrobial activities. M Read More

Background: Microwave technology is of great splendor in organic synthesis where it is applied efficaciously to synthesize a wide range of biologically active as well as industrially important compounds. Carbazole analogues are one of such important pharmacophores that are gaining considerable prominence nowadays. Besides their wide range of biological features, they possess opto-electronic as well as polymeric p Read More

Background: Cornus mas L. is a small tree of the Cornaceae plant family, widely spread in South Eastern Europe and Asia. The fruits of Cornus mas L. have been reported to possess anti-inflammatory, cardioand hepatoprotective, cytotoxic, antibacterial, antigenotoxic and diuretic effects. A high number of bioactive compounds have been identified in Cornus mas fruits, among which flavonoids exert favorable health effects especi Read More

Background: A number of atmospheric pollutants, such as polycyclic aromatic hydrocarbons, volatile organic compounds, and heavy metals, are monitored by environmental researchers. Among these atmospheric pollutants, polycyclic aromatic hydrocarbons play an important role owing to their nature, which is carcinogenic and toxic to human beings. A number of researchers have monitored these atmospheric pollutants u Read More

Objective: This review describes the discovery during the last five years of novel compounds with significant antimicrobial activity from marine actinomycetes; descriptions include their origins, relevant structures and antimicrobial activities. These antimicrobial compounds belong to several structural classes including alkaloids, peptides, polyketides, macrolides, glycosides, phenols and others. They further express antimicrobi Read More