Mini-Reviews in Organic Chemistry - Volume 10, Issue 2, 2013

Mitochondria are known to be the main players in important mitochondrial bioenergetic functions such as ATP synthesis, thermoregulatory energy dissipation, Ca2+ transport, generation of reactive oxygen species and mediation of intrinsic apoptosis. Naturally occurring polyamines, due to their high pka are almost completely protonated at physiological pH and behave as polycations in their interactions with mitochondrial memb Read More

The pyridazine moiety is an important and frequent antifeeedant, insecticidal, herbicidal, molluscicidal, plant growth regulatory activity and other agrochemical structural feature of many biologically active compounds. Recently, much attention has been focused on pyridazinone derivatives for their broad-spectrum activities. Substituted pyridazine derivatives were also reported to show antibacterial, antifungal, antiviral, properti Read More

The discovery of phosphodiesterase 10A (PDE10A) enzyme ligands as therapeutic agents in the treatment of central nervous system diseases, especially schizophrenia and Huntington’s disease nowadays is a competitive field developing rapidly, with many pharmaceutical companies involved in identifying a huge diversity of chemical scaffolds and molecular architectures for PDE10A interaction. Owing to the importan Read More

Salacinol was isolated as the first naturally occurring sulfonium type α-glucosidase inhibitor from Salacia reticulata, a large woody, climbing plant widely distributed in Sri Lanka and South India, in 1997. This compound presents a quite unique zwitterionic sulfonium sulfate structure and its α-glucosidase inhibitory activity (in vitro) was revealed to be as potent as those of anti-diabetics used in clinic. Since then, great efforts hav Read More

Sulfonamides (SO2–NH-) have been the center of drug structures as they are quite stable and well tolerated in human beings. The sulfonamides are very important protected intermediates of amines, with several types of biological activities. Due to the broad applicability of sulfonamides, it is desirable to find general and effective methods for their synthesis. Different methods have been adopted to synthesize sulfonamides. H Read More

Complementary hydrogen-bonding arrays are very important for the genetic information storage and transmission. Inspired by natural complementary hydrogen-bonding arrays, researchers have been developing many artificial examples, which have been used in the construction of functional materials. The aim of this review is to highlight the complementary hydrogen-bonding arrays for supramolecular polymerizations.

Recently, chemical cross coupling reactions have emerged as a powerful tool in the hands of synthetic organic chemist to synthesize complicated organic scaffolds like drugs, natural products, optical devices and industrially important materials. Stable N-Heterocyclic Carbene (NHC) acts as an important catalyst system in various cross coupling reactions. This review describes various strategies used for the synthesis of free and Read More

Chiral sulfoxides are extensively used in synthesis of chiral drugs, total synthesis of natural products and organic synthesis. Among them, chiral sulfoxide drugs in market or under research mostly have nitrogen-containing substructures. In common titanium catalysts have better catalytic property in asymmetric oxidation of these nitrogencontaining sulfide precursors than other catalysts. The ligands of these titanium catal Read More