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- Volume 10, Issue 5, 2010
Mini Reviews in Medicinal Chemistry - Volume 10, Issue 5, 2010
Volume 10, Issue 5, 2010
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Editorial [Hot topic: (Part I) Recent Trends in Anti-Cancer Drug Discovery (Guest Editor: Fazlul H. Sarkar)]
More LessBIOGRAPHY Fazlul H. Sarkar, Ph.D. is a professor of pathology at Karmanos Cancer Center, Wayne State University School of Medicine with a track-record of cancer research for 30 years. His research is focused on understanding the role of a “master” transcription factor, NF-κB and the regulation of its upstream and downstream signaling molecules in solid tumors. Moreover, his focused research has also been directed t Read More
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Cancer Stem Cells: A Novel Paradigm for Cancer Prevention and Treatment
Authors: D. Subramaniam, S. Ramalingam, C.W. Houchen and S. AnantCancer is the second leading cause for mortality in US only after heart disease and lacks a good or effective therapeutic paradigm. Despite the emergence of new, targeted agents and the use of various therapeutic combinations, none of the treatment options available is curative in patients with advanced cancer. A growing body of evidence is supporting the idea that human cancers can be considered as a stem cell disease. Read More
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Perspectives on Chemopreventive and Therapeutic Potential of Curcumin Analogs in Medicinal Chemistry
Authors: S. Padhye, D. Chavan, S. Pandey, J. Deshpande, K.V. Swamy and F.H. SarkarCurcumin is a natural polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over past 50 years has indicated that this polyphenol is highly pleiotropic molecule capable of preventing and treating various cancers. The anticancer potential of Curcumin is severely affected by its limited systemic and target tissue bioavailability and rapid metabolism. In the present review article, Read More
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Natural Products: Potential for Developing Phellodendron amurense Bark Extract for Prostate Cancer Management
Authors: A.P. Kumar, H. Graham, C. Robson, I.M. Thompson and R. GhoshOur ability to detect and treat most primary cancers has improved dramatically given the advances in our understanding of cancer biology. However, with increased life expectancy and our inability to treat or cure advanced stages of cancers, the number of cancer-related deaths is expected to double in the next decade. Epidemiological studies suggest that dietary factors are an important aspect that influences can Read More
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Pharmacological Exploitation of Indole-3-Carbinol to Develop Potent Antitumor Agents
Authors: J.-R. Weng, H.A. Omar, S.K. Kulp and C.-S. ChenThe antitumor activity of indole-3-carbinol is attributable to its ability to interfere with multiple oncogenic signaling pathways governing cell cycle progression, survival, invasion, and other aggressive phenotypes of cancer cells, especially those mediated by EGFR/Src, Akt, NF-κB, endoplasmic reticulum stress, and nuclear receptors. This broad spectrum of antitumor activities in conjunction with its metabolic instability constitut Read More
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Search for New and Novel Chemotherapeutics for the Treatment of Human Malignancies
Authors: A. Kamal, S. Azeeza, E.V. Bharathi, M.S. Malik and R.V.C.R.N.C. ShettiOne of the hallmarks of cancer is the uncontrolled cell proliferation which causes more deaths among the human diseases throughout the globe. One in eight deaths worldwide are due to cancer, it is the second and third leading cause of death in economically developed and developing countries, respectively. As it is caused by both external and internal factors, a balanced approach to cancer control includes prevention, Read More
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Perspectives on Medicinal Properties of Benzoquinone Compounds
Authors: P.R. Dandawate, A.C. Vyas, S.B. Padhye, M.W. Singh and J.B. BaruahBenzoquinones are class of natural quinones found chiefly in higher plants, fungi, bacteria and animal kingdom. They are involved in important biological functions such as bioenergetic transport, oxidative phosphorylation and electron transport processes. In recent years it has become increasingly clear that some of them possess potent antioxidant, anti-inflammatory and anticancer activities. There is clearly a common Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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Volume 5 (2005)
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Volume 4 (2004)
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Volume 3 (2003)
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Volume 2 (2002)
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Volume 1 (2001)
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