Mini Reviews in Medicinal Chemistry - Volume 10, Issue 11, 2010

Sol-gel technology is an impressive and instructive innovation in science that necessitates a multidisciplinary approach for its important applications in the practice. An important peculiarity of the sol gel technology is the possibility to control the mechanism and kinetics of the chemical reactions, thus monitoring the final structure (particle size, porosity, thin layer thickness) of the materials. The low processing temperature combin Read More

There has been a considerable interest in the development of novel compounds with anti-inflammatory and /or antimicrobial activities. Several economical and social merits have been prospected for compounds with dual effects. Pyrazoles are an important class of compounds for new drug development that attracted much attention. Several pyrazole derivatives have been synthesized as target structures and evaluated for t Read More

Epigenetic alterations occur throughout the development and carcinogenesis of gastric cancer. Therefore, the detection of methylated DNA markers is predicted to be able to detect gastric cancer earlier, and improve the risk assessment, surveillance, relapse, and prognosis of patients with gastric cancer. Detection of free methylated DNA also represents a promising approach for developing serum-based detection met Read More

The atmospheric pollutant sulfur dioxide (SO2) is endogenously generated from the normal metabolism of sulfur- containing amino acids through the aspartate aminotransferase pathway. SO2 is produced in cardiovascular tissues, and the aspartate aminotransferase mRNA is localized in endothelia and in vascular smooth muscle cells near the endothelial layer. Recent studies explored the physiological and pathophysiologi Read More

HIV-1 integrase (IN), which has no cellular counterpart, has been intensely studied over the past 15 years and has been fully validated as a therapeutic target with the first FDA approved IN inhibitor raltegravir. The quinolone acid GS-9137 (elvitegravir), which most probably will become the next candidate of IN inhibitors, is in the process of enrolling patients in the phase III clinical trials. This review focuses on small-molec Read More

The cell cycle is the series of events necessary for the division and duplication of a cell. The dysregulation of the cell cycle can promote the development of cancer. A group of proteins, cyclin-dependent kinases (CDKs), that control the cell cycle, provide new targets for treating cancer. As a result, cyclin-dependent kinase inhibitors (CDKIs) represent a novel class of chemotherapeutic agents. Of these, flavopiridol, a semi Read More

This review proposes a statistical and qualitative comparison between the main techniques derived from the original PAMPA method and experimental results obtained from Caco-2 and human jejunum. Among them, PAMPA techniques variations developed by some of the most renowned authors on the subject. The comparison is made from 16 common structurally diverse molecules, taking into account mainly Read More

This review covers natural products isolated from marine microorganisms including bacteria, fungi and actinomycetes published in the recent years. The emphasis is mainly about new compounds, together with their antibacterial activities, source organisms and country of origin, biosynthetic studies as well as the mechanisms involved in their anti-bacterial activities.