Letters in Organic Chemistry - Volume 12, Issue 6, 2015

The ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS) technique is a new approach in the chromatographic separations and has been successfully employed for fast, high resolution separations with required sensitivity. The TOF-MS is helpful in the structure elucidation and identification of fragmentation patterns of the compounds. This review provides the brief introdu Read More

One-pot, four component syntheses for the preparation of 1-H Pyrazolo[1,2-b]phthalazine- 5,10-diones (5a-5h) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13-H)-triones (7a-7f) have been described from phthaloyl dichloride (1) , hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a), ethyl cynoacetate (4b) or dimedone (6) in refluxing water for 1-1.5 h by in-situ generation of HCl as a catalyst. These reactions have eas Read More

A series of ten new 2,3,6-substituted quinazolin-4(3H)-one derivatives (10a-j) were prepared from anthranilic acid (1) in a simple and economical path in a series of reactions and screened for their anticancer activity against pancreatic cancer cell line (PANC-1) using MTT assay. The results reveal that at concentration 100 μM/L, compounds 10b, 10f, 10g and 10h exhibited potential anticancer activity by inhibiting the growth Read More

In this study, is reported a straightforward route is reported for the synthesis of a series of carbamazepine derivatives using some strategies. The first stage was achieved by the reaction of carbamazepine with thiourea in the presence of pyridine to form the compound 3-(5H-dibenzo[b,f]azepin-5-yl)-2,5-dihydro-1,2,4-thiadiazol-5-amine (3). After 3 was made reacting with chloroacetyl chloride using triethylamin Read More

The new index for the evaluation of the aromatic character based on the energy of π orbitals.

A series of ten new 2,3,6-substituted quinazolin-4(3H)-one derivatives (10a-j) were prepared from anthranilic acid (1) in a simple and economical path in a series of reactions and screened for their anticancer activity against pancreatic cancer cell line (PANC-1) using MTT assay. The results reveal that at concentration 100 µM/L, compounds 10b, 10f, 10g and 10h exhibited potential anticancer activity by inhibiting the growth Read More

Synthesis of the trisaccharide, benzyl 2-acetamido-3,6-di-O-benzyl-2-deoxy-β-Dglucopyranosyl-(1→3)-2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(1→4)-2,3,6-tri-O-benzyl-β-Dglucopyranoside (9), was achieved from building block derivatives of the component mono- and disaccharide units. Initially the benzyl lactoside acceptor 3, which has a free hydroxyl group at position O-3`, was prepared via selective opening of the 3',4' Read More

An efficient eco-friendly approach has been adopted for the selective synthesis of 2,3- epoxypropylsulfanyltriazole 4 from the reaction of 1-chloro-2,3-epoxy-propane (2) with 5-(3- chlorobenzo[b]thien-2-yl)-4H-1,2,4-triazole-3-thione (1) under solvent free microwave conditions in the presence of a solid support. Instead, when the mixture of reactants was irradiated for prolonged time in the absence of solid support, triazolo[ 2,1 Read More

A concise stereoselective total synthesis of (-) - Cephalosporolide D, an eight membered lactone ring has been derived from low cost and easily available starting material (±)-propylene epoxide. The key steps involved in this concise synthesis are Sharpless kinetic resolution, Grignard reaction and Yamaguchi macrolactonisation.