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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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UHPLC/Q-TOF-MS Technique: Introduction and Applications
- Source: Letters in Organic Chemistry, Volume 12, Issue 6, Jul 2015, p. 371 - 378
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- 01 Jul 2015
Abstract
The ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS) technique is a new approach in the chromatographic separations and has been successfully employed for fast, high resolution separations with required sensitivity. The TOF-MS is helpful in the structure elucidation and identification of fragmentation patterns of the compounds. This review provides the brief introduction and applications of UHPLC/Q-TOF-MS with examples of some of the most advanced work in the pharmaceutical analysis.
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