Letters in Organic Chemistry - Volume 12, Issue 10, 2015

A clean and environmentally benign route to 2-amino-4H-chromenes has been developed using the reaction between various benzaldehydes, malononitrile and α-naphthol in the presence of 3,3'-(pentane-1,5-diyl)bis(1,2-dimethyl-1H-imidazol-3-ium) bromide. The present methodology offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions and reduced environment Read More

In this work, palladium nanoparticles/graphene/SBA-15 (Pd/G/SBA-15) nanocomposites were fabricated using a facile method and characterized by XRD, SEM, TEM, and FT-IR, respectively. The as-prepared Pd/G/SBA-15 exhibited high catalytic activity for the Suzuki coupling reaction. The catalyst can be easily recycled and reused at least four times without a remarkable loss of its catalytic activity.

In this study some estradiol derivatives were prepared using different strategies. The first stage was achieved by the preparation of an estradiol-dicarbaldehyde derivative (compound 2) by the reaction of estradiol with dimethyl sulfoxide (method A) or with Cooper(II) reagent in the presence of ethylenediamine (method B). The following stage was achieved by synthesis of the steroid-oxadiazin ester derivative (compound 5) us Read More

Using various chromatography methods, five steroids and two brominated lipids (1-7), 3β- hydroxy-5-cholenic acid methyl ester, stigmasta-5,24(28)-dien-3β,29-diol, 24-methylenecholest-4-en- 3β,6β-diol, cholest-5-en-3β,7β-diol, 24-vinylcholest-5-en-3β,24-diol, xestospongiene A, and xestospongiene J, respectively, were isolated from the methanol extract of Vietnamese marine sponge Haliclona oculata (Linnaeus, 175 Read More

A highly efficient and environmentally benign protocol for the synthesis of 8-amino-6-aryl-1,2-dihydro-2-oxo-6H-pyrano[2,3-e]benzoxazole-7-carbonitrile derivatives by one-pot three-component coupling reacting of aromatic aldehydes, malononitrile and 4-hydroxy-2(3H)-benzoxazolone under reflux condition has been developed in aqueous media using Na2O-Al2O3-P2O5 glass-ceramic system.

An efficient and simple way to synthesize N-(β-nitroalkyl) amides with broad substrate spectrum was developed. Various β-nitroarylethanols and nitriles were suitable substrate for the protocol. A series of N-(β-nitroalkyl) amides were synthesized through Ritter reaction and the yield is up to 95%.

Seven heterocyclic compounds derived from isatin have been synthesized. Isatin was N-substituted with four aromatic/aliphatic and benzylic moieties (1a-d). Compounds 1a-c were condensed with o-phenylenediamine to afford indoloquinoxaline derivatives (2a-c). Products were tested as inhibitors of InhA enzyme of M. tuberculosis. Compound 6-(diethylaminoethyl)indoloquinoxaline (2a) inhibited 38% of InhA activity at 50 Read More

The use of multicomponent reactions as potential synthetic processes, ionic liquids as catalysts and water as reaction medium is a suitable approach that respects, in some extent, the requirements of sustainable chemistry. In this context, we report, herein, an efficient and high yielding four-component synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles involving ethyl acetoacetate, hyd Read More

An effective and improved process for the preparation of cis-cyclopro panediamine dihydrochloride was developed in a 100 g scale. The key step in the process is the preparation of ciscyclopropane- 1, 2-dicarboxylic acid from a mixture of cis- and trans- isomers by the formation of cyclic acidic anhydride. The whole process and all of the procedures are economical, industrially reliable and easily scaled up.

This work demonstrates the effective total synthesis of a new broad-spectrum parenteral carbapenem starting from the readily available and inexpensive N-Cbz-protected glycine amide in high yield with easy work-up under mild reaction conditions.

Novel series of 2-(4-chloro,6-morpholino-1,3,5-triazin-2-yl) amino acid ester derivatives and 2-(4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid ester derivatives were synthesized using simple one pot method in acetone–water in the presence of K2CO3 as HCl scavenger. The products were obtained in high yields and purities as observed from their spectral data, elemental analyses and mass spectra. The anti-proliferation ac Read More