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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Biological Evaluation of Some New Indolizine Derivatives as Antitumoral Agents
- Source: Letters in Drug Design & Discovery, Volume 13, Issue 6, Jul 2016, p. 479 - 488
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- 01 Jul 2016
Abstract
A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS cancer cell line for 1-cyanoindolizine derivative 10b. Moreover, a supplementary in vitro biological evaluation showed that compound 9d exhibited a significant farnesyltransferase inhibition activity (IC50 = 1.07 ± 0.34 μM) and could represent a lead for the development of new antitumoral chemical entities.
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