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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7
- Source: Letters in Drug Design & Discovery, Volume 13, Issue 6, Jul 2016, p. 489 - 494
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- 01 Jul 2016
Abstract
A series of macamides (1-4) and their synthetic analogs (5-14) were synthesized and evaluated for in vitro inhibitory activities against breast cancer cell MCF-7. The results of bioactive assay showed that two of the macamides (compound 1 and 4) and one synthetic analog (compound 5) displayed comparable inhibitory activities against MCF-7 cell line, with IC50 values of 29.6, 36.2 and 27.2 μM, respectively.
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