Full text loading...
- ISSN: 1570-1808
- E-ISSN: 1875-628X
-
Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive
- Source: Letters in Drug Design & Discovery, Volume 13, Issue 6, Jul 2016, p. 475 - 478
-
- 01 Jul 2016
- Previous Article
- Table of Contents
- Next Article
Abstract
An efficient method was developed for the synthesis of pamidronic acid involving the reaction of β-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 °C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.
© Bentham Science Publishers