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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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First In Vivo Evaluation of a New Morpholine Analog
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 7, Oct 2007, p. 520 - 523
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- 01 Oct 2007
Abstract
The scope of 6,8-dioxa-3-aza-bicyclo(3.2.1)octane derivatives as morpholine replacing groups in bioactive compounds was investigated. Four derivatives were synthesized and subjected to the routinary screening strategy, as part of a project directed to obtain new tachykinin NK2 antagonists. The obtained results encourage further study on the heterobicycle 6,8-dioxa-3-aza-bicyclo(3.2.1)octane as morpholine surrogate.
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