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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Artemisinin Delays Sphingolipid Biosynthesis in Plasmodium falciparum
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 7, Oct 2007, p. 524 - 526
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- 01 Oct 2007
Abstract
Artemisinin induces the growth inhibition of Plasmodium falciparum by sphingomyelinase-generated ceramide. To understand whether artemisinin could have another effect, sphingolipid biosynthesis was studied. Our result shows that a delay in the formation of final products (globoside, cerebrosides) production might be involved in the increase of ceramide.
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