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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Antibacterial Activity of 3-Substituted Pyrrole-2,5-diones Against Pseudomonas Aeruginosa
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 7, Oct 2007, p. 513 - 519
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- 01 Oct 2007
Abstract
3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents.
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