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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and In Vitro Biochemical Evaluation of a Series of Cycloalkyl Esters of 4-Sulfamoylated Benzoic Acid as Inhibitors of Estrone Sulfatase (ES)
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 6, Sep 2007, p. 399 - 403
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- 01 Sep 2007
Abstract
We report the results of the synthesis and biochemical evaluation of esters of 4-[(aminosulfonyl)oxy]benzoate as potential inhibitors of estrone sulfatase (ES). Modelling the compounds shows that steric interaction between the inhibitor and the active site is a major factor responsible for the weak inhibitory activity observed within the synthesised compounds.
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