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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Anti-HSV-1 Activity of 1,4-dihydro-4-oxoquinoline Ribonucleosides
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 6, Sep 2007, p. 404 - 409
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- 01 Sep 2007
Abstract
Oxoquinolineribonucleosides 1a-j were prepared. These substances were screened for antiviral activity on HSV-1 virus infection, assessed by virus yield assay. The chlorosubstituted ribonucleosides 1b and 1g were the best inhibitors of HSV-1 yield with EC50 of 1.5 ± 0.06 μM and 1.7 ± 0.08 μM, respectively. Compound 1b presented the best selectivity index (SI) with an SI value of 1000.
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