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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and In Vitro Biochemical Evaluation of a Series of Compounds as Potential Inhibitors of Estrone Sulfatase (ES) and the Role of pKa in both the Synthesis and the Inhibitory Activity of the Potential Inhibitors
- Source: Letters in Drug Design & Discovery, Volume 4, Issue 6, Sep 2007, p. 394 - 398
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- 01 Sep 2007
Abstract
We report the results of our study into a series of 3,5-dibrominated derivatives of esters of 4- [(aminosulfonyl)oxy]benzoate as potential inhibitors of estrone sulfatase (ES). The results suggest that the compounds are weak inhibitors as a result of the incorporation of the bromine atoms which reduce the stability of the compound.
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