Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines

Luiz Everson da Silva; Antonio Carlos Joussef; Leticia Kramer Pacheco; Danielle Bibas Legat Albino; Anita Mauricio Camilo Duarte; Mario Steindel; Ricardo Andrade Rebelo

doi:10.2174/157018007779422550

ISSN: 1570-1808
E-ISSN: 1875-628X

Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines
Authors: Luiz Everson da Silva¹, Antonio Carlos Joussef², Leticia Kramer Pacheco³, Danielle Bibas Legat Albino⁴, Anita Mauricio Camilo Duarte⁵, Mario Steindel⁶ and Ricardo Andrade Rebelo⁷
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¹ Universidade Federal de Mato Grosso, Departamento de Quimica, Av. Fernando Correa da Costa,Coxipo, Cuiaba- Mato Grosso, Cep 78060-900, Brazil. ² Universidade Federal de Mato Grosso, Departamento de Quimica, Av. Fernando Correa da Costa,Coxipo, Cuiaba- Mato Grosso, Cep 78060-900, Brazil. ³ Universidade Federal de Mato Grosso, Departamento de Quimica, Av. Fernando Correa da Costa,Coxipo, Cuiaba- Mato Grosso, Cep 78060-900, Brazil. ⁴ Universidade Federal de Mato Grosso, Departamento de Quimica, Av. Fernando Correa da Costa,Coxipo, Cuiaba- Mato Grosso, Cep 78060-900, Brazil. ⁵ Universidade Federal de Mato Grosso, Departamento de Quimica, Av. Fernando Correa da Costa,Coxipo, Cuiaba- Mato Grosso, Cep 78060-900, Brazil. ⁶ Universidade Federal de Mato Grosso, Departamento de Quimica, Av. Fernando Correa da Costa,Coxipo, Cuiaba- Mato Grosso, Cep 78060-900, Brazil. ⁷ Universidade Federal de Mato Grosso, Departamento de Quimica, Av. Fernando Correa da Costa,Coxipo, Cuiaba- Mato Grosso, Cep 78060-900, Brazil.
Source: Letters in Drug Design & Discovery, Volume 4, Issue 2, Mar 2007, p. 154 - 159
DOI: https://doi.org/10.2174/157018007779422550
- Available online: 01 Mar 2007

Abstract

The leishmanicidal and trypanocidal activities of chlorinated 1,7- and 1,8-naphthyridines were evaluated against cultured of L. amazonensis promastigote and T. cruzi epimastigote forms. Active compounds were also tested against blood trypomastigotes and their toxicity to Vero cells. Among the compounds evaluated 10 was the most active against L. amazonensis promastigotes and T. cruzi epimastigotes, IC50= 8.6 μM and IC50 =20.4 μM, respectively.

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2007-03-01

2025-05-27

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Article Type: Research Article

Keyword(s): Antiparasitic; Chloronaphthyridines; Trypanocidal and Leishmanicidal activities

Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines

Abstract

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