BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury

Roy Asaf; Shany Blum; Rachel Miller-Lotan; Andrew P. Levy

doi:10.2174/157018007779422479

ISSN: 1570-1808
E-ISSN: 1875-628X

BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury
Authors: Roy Asaf¹, Shany Blum², Rachel Miller-Lotan³ and Andrew P. Levy⁴
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¹ Technion Faculty of Medicine, Haifa, 31096, Israel. ² Technion Faculty of Medicine, Haifa, 31096, Israel. ³ Technion Faculty of Medicine, Haifa, 31096, Israel. ⁴ Technion Faculty of Medicine, Haifa, 31096, Israel.
Source: Letters in Drug Design & Discovery, Volume 4, Issue 2, Mar 2007, p. 160 - 162
DOI: https://doi.org/10.2174/157018007779422479
- Available online: 01 Mar 2007

Abstract

Oxidative stress is responsible for myocardial injury occurring after ischemia and reperfusion (IR) and has been shown to be modulated by the Haptoglobin (Hp) genotype. In this manuscript we demonstrate that the antioxidant BXT -51072, a glutathione peroxidase synthetic mimic, provides protection against IR injury in a Hp genotype dependent fashion.

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2007-03-01

2025-05-28

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Article Type: Research Article

Keyword(s): BXT-51072; Diabetes; Myocardial ischemia-reperfusion; Oxidative stress

BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury

Abstract

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