Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions

Mauro Vieira De Almeida; Marcus Vinicius de Nora Souza; Nadia Rezende Barbosa; Frederico Pittella Silva; Giovanni Wilson Amarante; Sílvia Helena Cardoso

doi:10.2174/157018007779422514

ISSN: 1570-1808
E-ISSN: 1875-628X

Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions
Authors: Mauro Vieira De Almeida¹, Marcus Vinicius de Nora Souza², Nadia Rezende Barbosa³, Frederico Pittella Silva⁴, Giovanni Wilson Amarante⁵ and Sílvia Helena Cardoso⁶
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¹ Departamento de Quimica,ICE, Universidade Federal de Juiz de Fora, 36036-330 - Juiz de Fora, MG,Brazil. ² Departamento de Quimica,ICE, Universidade Federal de Juiz de Fora, 36036-330 - Juiz de Fora, MG,Brazil. ³ Departamento de Quimica,ICE, Universidade Federal de Juiz de Fora, 36036-330 - Juiz de Fora, MG,Brazil. ⁴ Departamento de Quimica,ICE, Universidade Federal de Juiz de Fora, 36036-330 - Juiz de Fora, MG,Brazil. ⁵ Departamento de Quimica,ICE, Universidade Federal de Juiz de Fora, 36036-330 - Juiz de Fora, MG,Brazil. ⁶ Departamento de Quimica,ICE, Universidade Federal de Juiz de Fora, 36036-330 - Juiz de Fora, MG,Brazil.
Source: Letters in Drug Design & Discovery, Volume 4, Issue 2, Mar 2007, p. 149 - 153
DOI: https://doi.org/10.2174/157018007779422514
- Available online: 01 Mar 2007

Abstract

A series of C-2 and C-6 substituted pyridines was synthesized and evaluated in vitro against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans and Candida albicans. Most of compounds exhibited a wide range of modest in vitro activity against the tested microorganisms.

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2007-03-01

2025-05-31

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Article Type: Research Article

Keyword(s): Amide; Antimicrobial activity; Substituted pyridines; Synthesis

Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions

Abstract

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