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image of Synthesis of New Xanthene and Acridine Derivatives from Cyclohexan-1,3-dione and the Study of their Antiproliferative Activities

Abstract

Background

Ionic immobilized liquids and multi-component reactions are integral to green chemistry, facilitating the synthesis of biologically active compounds, such as xanthene and acridine derivatives. These approaches have garnered significant attention in recent years.

Objective

The aim of this study was to synthesize novel xanthene and acridine derivatives with diverse substituents and heterocyclic rings. Furthermore, the research sought to evaluate their anticancer activity against various cancer cell lines and analyze their structure-activity relationships (SAR) to determine how structural modifications impact their biological effectiveness.

Method

The core compounds in this study were synthesized from cyclohexane-1,3-dione and triethoxymethane under two distinct reaction conditions. The first involved the use of a solvent with either EtN or NHOAc as a catalyst, while the second employed a solvent-free approach using an ionic liquid catalyst (ILs).

Results

The anti-proliferative activity of all synthesized compounds was evaluated against six selected cancer cell lines, revealing that many compounds exhibited significant inhibitory effects. Furthermore, their inhibitory potential against tyrosine kinases and Pim-1 kinases was assessed, along with an investigation of their mechanism of action on tyrosine kinases.

Conclusion

The anti-proliferative activity of the newly synthesized compounds was evaluated against six cancer cell lines. Many of the compounds exhibited strong inhibitory effects not only against the tested cancer cell lines but also against tyrosine kinases and Pim-1 kinases.

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2024-10-29
2024-11-26

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/content/journals/lddd/10.2174/0115701808336532241009105320
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Synthesis of New Xanthene and Acridine Derivatives from Cyclohexan-1,3-dione and the Study of their Antiproliferative Activities
Bentham Science Publishers ; https://doi.org/10.2174/0115701808336532241009105320
/content/journals/lddd/10.2174/0115701808336532241009105320
/content/journals/lddd/10.2174/0115701808336532241009105320
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  • Article Type:     Research Article
Keywords: tyrosine kinases ; xanthene ; cytotoxicity ; Cyclohexan-1,3-dione ; multicomponent ; acridine

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