Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Letters in Drug Design & Discovery
  4. Volume 21, Issue 17
  5. Article
Volume 21, Issue 17
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background

The synthesis of metal-based nanoparticles through conventional methods involves harsh conditions, high costs, and severe environmental threats. To overcome these issues, researchers are nowadays focusing on eco-friendly and low-cost methods for the synthesis of nanoparticles. Finally, several plant-mediated synthesis techniques have been developed, which have various advantages, such as low-cost, environmentally friendly, and easy application. The plant extract not only serves as a reducing agent but also plays a role as a stabilizing agent. The plant-mediated synthesis provides new opportunities for cost-effective, environmentally-friendly nanoparticle synthesis with high dispersity and stability. Besides, bio-generated nanoparticles derived from plant extract have promising pharmacological applications, making them potential candidates for future medicines.

Aims and Objectives

The current study aimed to synthesize zirconium oxide nanoparticles using extract and examine their physicochemical properties. Additionally, the antimicrobial efficacy of these nanoparticles was evaluated against various pathogens, exploring their potential as potent antimicrobial agents.

Methods

The synthesized nanoparticles were analyzed and characterized by various techniques like UV-Vis spectroscopy, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Energy Dispersive X-ray spectroscopy (EDX). The UV-visible peak at 216 nm confirmed the formation of ZrO nanoparticles. The SEM images clearly showed that nanoparticles were spherical and relatively dispersed, with few agglomerations. The EDX spectra confirmed the existence of zirconium and oxygen as the basic constituents of the sample. TEM images demonstrated nanoparticles as spherical and uniformly dispersed but agglomerated with increasing precursor concentrations and decreasing nanoparticle dispersion. Fluconazole and gentamicin were used as standards in determining the antibacterial and antifungal activities of nanoparticles.

Results

Considering the antifungal activity, a maximum zone of inhibition of 16 µg/ml was demonstrated in the case of 2 mM as compared to 4 mM and 6 mM concentrations. The -mediated ZrO nanoparticles were screened against Gram-positive ( and ) and Gram-negative ( and ) bacterial strains. The fabricated nanoparticles exhibited promising action against all microorganisms.

Conclusion

In the current study, zirconium oxide nanoparticles were synthesized by using leaves extract as a reducing agent. The antifungal and antibacterial potential of the synthesized nanoparticles were evaluated. The green synthesis method used in this study is preferable to the others as it is more affordable, environmentally benign, and widely accessible.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/lddd/10.2174/0115701808317324240903094558
2024-09-11
2025-05-29

  • From This Site

    /content/journals/lddd/10.2174/0115701808317324240903094558
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. ShaY. MathewI. CuiQ. ClayM. GaoF. ZhangX.J. GuZ. Rapid degradation of azo dye methyl orange using hollow cobalt nanoparticles.Chemosphere20161441530153510.1016/j.chemosphere.2015.10.040 26498101
     [Google Scholar]
  2. AminaS.J. IqbalM. FaisalA. ShoaibZ. NiaziM.B.K. AhmadN.M. KhalidN. JanjuaH.A. Synthesis of diosgenin conjugated gold nanoparticles using algal extract of Dictyosphaerium sp. and in-vitro application of their antiproliferative activities.Mater. Today Commun.20212710236010.1016/j.mtcomm.2021.102360
     [Google Scholar]
  3. KarthikeyanB. LoganathanB. Rapid green synthetic protocol for novel trimetallic nanoparticles. J. Nanopart.,201310.1155/2013/168916
     [Google Scholar]
  4. AllaediniG. TasirinS.M. AminayiP. Synthesis of Fe–Ni–Ce trimetallic catalyst nanoparticles via impregnation and co-precipitation and their application to dye degradation.Chem. Pap.201670223124210.1515/chempap‑2015‑0190
     [Google Scholar]
  5. ZhanY. LiuY. ZuH. GuoY. WuS. YangH. LiuZ. LeiB. ZhuangJ. ZhangX. HuangD. HuC. Phase-controlled synthesis of molybdenum oxide nanoparticles for surface enhanced Raman scattering and photothermal therapy.Nanoscale201810135997600410.1039/C8NR00413G 29542776
     [Google Scholar]
  6. ToshimaN. Capped bimetallic and trimetallic nanoparticles for catalysis and information technology.Macromolecular Symposia,20082701273910.1002/masy.200851004
     [Google Scholar]
  7. AlsharariS.S. AleneziM.A. Al TamiM.S. SolimanM. Recent advances in the biosynthesis of zirconium oxide nanoparticles and their biological applications.Baghdad Sci J.2023201004110.21123/bsj.2022.7055
     [Google Scholar]
  8. FaucheuJ. Bourgeat-LamiE. PrevotV. A review of vanadium dioxide as an actor of nanothermochromism: Challenges and perspectives for polymer nanocomposites.Adv. Eng. Mater.2019212180043810.1002/adem.201800438
     [Google Scholar]
  9. DługoszO. SzostakK. BanachM. Photocatalytic properties of zirconium oxide–zinc oxide nanoparticles synthesised using microwave irradiation.Appl. Nanosci.202010394195410.1007/s13204‑019‑01158‑3
     [Google Scholar]
  10. RaniN. SinghP. KumarS. KumarP. BhankarV. KumarK. Plant-mediated synthesis of nanoparticles and their applications: A review.Mater. Res. Bull.202316311223310.1016/j.materresbull.2023.112233
     [Google Scholar]
  11. MathersR.T. MeierM.A. Green polymerization methods: renewable starting materials, catalysis and waste reduction.John Wiley & Sons201110.1002/9783527636167
     [Google Scholar]
  12. JI, X.; GUO, J.; TIAN, J.; MA, K.; LIU, Y. Research progress on degradation methods and product properties of plant polysaccharides.J. Light Indust.2023385562
     [Google Scholar]
  13. ZhangL. ShiH. TanX. JiangZ. WangP. QinJ. Ten-gram-scale mechanochemical synthesis of ternary lanthanum coordination polymers for antibacterial and antitumor activities.Front Chem.20221089832410.3389/fchem.2022.898324 35774860
     [Google Scholar]
  14. NguyenD.T.C. TranT.V. NguyenT.T.T. NguyenD.H. AlhassanM. LeeT. New frontiers of invasive plants for biosynthesis of nanoparticles towards biomedical applications: A review.Sci. Total Environ.2023857Pt 215927810.1016/j.scitotenv.2022.159278 36216068
     [Google Scholar]
  15. HeX. JiangZ. AkakuruO.U. LiJ. WuA. Nanoscale covalent organic frameworks: From controlled synthesis to cancer therapy.Chem. Commun. (Camb.)20215793124171243510.1039/D1CC04846E 34734601
     [Google Scholar]
  16. ArgenzianoR. Agustin-SalazarS. PanaroA. CalarcoA. Di SalleA. ApreaP. CerrutiP. PanzellaL. NapolitanoA. Combining the potent reducing properties of pecan nutshell with a solvent-free mechanochemical approach for synthesizing high Ag0 content-silver nanoparticles: An eco-friendly route to an efficient multifunctional photocatalytic, antibacterial, and antioxidant material.Nanomaterials (Basel)202313582110.3390/nano13050821 36903701
     [Google Scholar]
  17. WangY. ZhaiW. ChengS. LiJ. ZhangH. Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis.Friction20231181371139410.1007/s40544‑022‑0710‑x
     [Google Scholar]
  18. GoyalP. BhardwajA. MehtaB.K. MehtaD. Research article green synthesis of zirconium oxide nanoparticles (ZrO2NPs) using Helianthus annuus seed and their antimicrobial effects.J. Indian Chem. Soc.202198810008910.1016/j.jics.2021.100089
     [Google Scholar]
  19. TanT. FengY. WangW. WangR. YinL. ZengY. ZengZ. XieT. Cabazitaxel-loaded human serum albumin nanoparticles combined with TGFβ-1 siRNA lipid nanoparticles for the treatment of paclitaxel-resistant non-small cell lung cancer.Cancer Nanotechnol.20231417010.1186/s12645‑023‑00194‑7
     [Google Scholar]
  20. MengZ. TanY. DuanY. LiM. MonaspinB. Monaspin B, a novel cyclohexyl-furan from cocultivation of Monascus purpureus and Aspergillus oryzae, exhibits potent antileukemic activity.J. Agric. Food Chem.20247221114112310.1021/acs.jafc.3c08187 38166364
     [Google Scholar]
  21. Sai SaraswathiV. SanthakumarK. Photocatalytic activity against azo dye and cytotoxicity on MCF-7 cell lines of zirconium oxide nanoparticle mediated using leaves of Lagerstroemia speciosa.J. Photochem. Photobiol. B2017169475510.1016/j.jphotobiol.2017.02.023 28273504
     [Google Scholar]
  22. LuoY. ZhaoJ. ZhangX. WangC. WangT. JiangM. ZhuQ. XieT. ChenD. Size controlled fabrication of enzyme encapsulated amorphous calcium phosphate nanoparticle and its intracellular biosensing application.Colloids Surf. B Biointerfaces202120111163810.1016/j.colsurfb.2021.111638 33639505
     [Google Scholar]
  23. RasheedP. HaqS. WaseemM. RehmanS.U. RehmanW. BibiN. ShahS.A.A. Green synthesis of vanadium oxide-zirconium oxide nanocomposite for the degradation of methyl orange and picloram.Mater. Res. Express20207202501110.1088/2053‑1591/ab6fa2
     [Google Scholar]
  24. XuT. YanX. KangA. YangL. LiX. TianY. YangR. QinS. GuoY. Development of membrane-targeting fluorescent 2-Phenyl-1 H -phenanthro[9,10- d]imidazole-antimicrobial peptide mimic conjugates against methicillin-resistant Staphylococcus aureus.J. Med. Chem.202467119302931710.1021/acs.jmedchem.4c00436 38491982
     [Google Scholar]
  25. HuB. DasP. LvX. ShiM. AaJ. WangK. DuanL. GilbertJ.A. NieY. WuX. Effects of ‘healthy’ fecal microbiota transplantation against the deterioration of depression in fawn-hooded rats.mSystems20227e21822
     [Google Scholar]
  26. SinghR. SmithaM.S. SinghS.P. The role of nanotechnology in combating multi-drug resistant bacteria.J. Nanosci. Nanotechnol.20141474745475610.1166/jnn.2014.9527 24757944
     [Google Scholar]
  27. DalalV. DhankharP. SinghV. SinghV. RakhaminovG. Golemi-KotraD. KumarP. Structure-based identification of potential drugs against FmtA of Staphylococcus aureus: Virtual screening, molecular dynamics, MM-GBSA, and QM/MM.Protein J.202140214816510.1007/s10930‑020‑09953‑6 33421024
     [Google Scholar]
  28. SinghV. DhankharP. DalalV. TomarS. Golemi-KotraD. KumarP. Drug-repurposing approach to combat Staphylococcus aureus : Biomolecular and binding interaction study. ACS Omega,2022743384483845810.1021/acsomega.2c03671
     [Google Scholar]
  29. KabirM.A. HussainM.A. AhmadZ. Candida albicans: A model organism for studying fungal pathogens.ISRN Microbiol.2012201211510.5402/2012/538694 23762753
     [Google Scholar]
  30. VanlalveniC. LallianrawnaS. BiswasA. SelvarajM. ChangmaiB. RokhumS.L. Green synthesis of silver nanoparticles using plant extracts and their antimicrobial activities: A review of recent literature.RSC Advances20211152804283710.1039/D0RA09941D 35424248
     [Google Scholar]
/content/journals/lddd/10.2174/0115701808317324240903094558
Loading
Carya Illinoinensis-mediated Green Synthesis and Antimicrobial Screening of Zirconium Oxide Nanoparticles: The Promising Antimicrobial Agent
Letters in Drug Design & Discovery 21, 3998 (2024); https://doi.org/10.2174/0115701808317324240903094558
/content/journals/lddd/10.2174/0115701808317324240903094558
/content/journals/lddd/10.2174/0115701808317324240903094558
Loading

Data & Media loading...


  • Article Type:     Research Article
Keyword(s): Carya illinoinensis; fluconazole; gentamicin; gram-negative; leaves extract; nanoparticles; Zirconium oxide

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test