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Volume 21, Issue 14
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background

, a naturally occurring herb, is utilized in medicinal formulations. It possesses abundant bioactive elements, including flavonoids and phenolic acid compounds, that exhibit various properties such as antioxidants, anti-inflammatory and anti-cancer.

Objective

In the present study, chemical constituents of essential oil extracted from were analyzed and identified through GC-MS. antiproliferative activity was performed on A549 lung cancer cell line lines. study was conducted by Schrodinger’s Maestro’s software to identify chemical constituents in the plant as potential EGFR (Epidermal Growth Factor Receptors) inhibitors.

Methods

Hydro-distilled essential oil was analyzed by GC-MS to identify chemical components based on the retention index and mass fragmentation pattern, which was then tested for its antiproliferative activity by MTT assay against human lung cancer cell lines. All the identified constituents were investigated for their affinity towards EGFR (Epidermal Growth Factor Receptors).

Results

A total of thirty constituents were identified where D-carvone (56.69%), L-limonene (12.36%), squalene (3.36%), cis-carveol (2.93%), and α-amorphene (2.36%) were observed as major constituents of the essential oil. The essential mentha oil also exhibited antiproliferative activity against lung cancer cell lines with an IC value of 86.05 µg/ml. Furthermore, from the study, five constituents were identified to have a better affinity for EGFR (Epidermal Growth Factor Receptors) than that of the standard drug Osimertinib.

Conclusion

In the present study, the aerial part of the plant was hydrodistilled. Thirty phytoconstituents were identified through GC-MS data. An study was performed using Schrodinger software, and a further study was performed in which essential oil showed good anti proliferative activity against the A549 cancer cell line.

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2024-11-01
2024-11-19

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Chemical Composition, In vitro and In silico Evaluation of Essential Oil Extracted from Mentha Piperita L. for Lung Cancer
Letters in Drug Design & Discovery 21, 3018 (2024); https://doi.org/10.2174/0115701808266939231011044527
/content/journals/lddd/10.2174/0115701808266939231011044527
/content/journals/lddd/10.2174/0115701808266939231011044527
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  • Article Type:     Research Article
Keyword(s): ADME; essential oil; in silico; in vitro; Lung cancer; Mentha piperita; MMGBSA

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