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Volume 21, Issue 15
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Introduction

Breast cancer is one of the most prevalent malignancies among women around the world. , a natural food coloring and flavoring, has potent anti-tumor properties. The aim of the current study was to investigate the therapeutic potential of crocin, the main pharmacological active component of saffron, either alone or in combination with the standard chemotherapeutic treatment, 5-FU, in Breast cancer (BC) progression in both cellular and animal models.

Material and Methods

MTT, Real-Time PCR, Western Blotting, Hematoxylin and eosin () tissue staining were applied to determine the anti-tumor properties of crocin in and samples.

Results

Our findings showed that crocin decreased breast cancer cell proliferation by suppressing cyclin D1 expression and Wnt/β-catenin signaling activation. Moreover, this molecule improved 5-FU anti-cancer activities by decreasing the tumor volume and weight, increasing tumor necrosis, and suppressing tumor inflammation in an animal model. Inflammation-associated anti-cancer activity of crocin is mediated by the down-regulation of pro-inflammatory genes, including IFN-γ and IL-1β, as well as inhibition of oxidative stress responses within the tumor environment.

Conclusion

This is the first study demonstrating the potent anti-tumor properties of crocin against BC progression. Our results suggest that this effective and low-toxic molecule could be a promising agent for reducing BC tumor progression when administered either alone or in combination with standard treatment in breast cancer patients.

© 2024 Bentham Science Publishers
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2024-01-23
2024-12-29

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/content/journals/lddd/10.2174/0115701808258032231204080133
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Crocin Potentiates Anti-tumor Properties of 5-FU by Regulating Cell Proliferation and Tumor Necrosis in Breast Cancer
Letters in Drug Design & Discovery 21, 3161 (2024); https://doi.org/10.2174/0115701808258032231204080133
/content/journals/lddd/10.2174/0115701808258032231204080133
/content/journals/lddd/10.2174/0115701808258032231204080133
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  • Article Type:     Research Article
Keyword(s): 5-FU; breast cancer; crocin; malondialdehyde; Saffron

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