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Volume 21, Issue 15
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background

Previously restricted to remote areas of Central and Western Africa, the MPOX virus-based disease, also known as monkeypox, has now spread to more than 90 countries and has become endemic. As a consequence, the MPOX virus has become a global public health concern.

Objective

The objective of this study was to conduct a computational-multiparametric study (at the genomic and proteomic levels) of the biological sequences that express the MPOX virus envelopes in order to fathom the physicochemical regularities of these proteins.

Methods

Using computer programs, we determined the polarity index method (PIM) profile and protein intrinsic disorder predisposition (PIDP) for each studied protein.

Results

The UniProt database was able to identify sequences similar to those of the MPOX virus expressed thanks to the computational regularities found in the virus' envelope sequences.

Conclusion

The polarity index method and protein intrinsic disorder predisposition profiles could aid in elucidating the sequence-level structural regularities of the MPOX virus envelopes.

© 2024 Bentham Science Publishers
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2023-11-08
2025-04-06

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/content/journals/lddd/10.2174/0115701808260478231023080842
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Bioinformatics-based Analysis of the Variability of MPOX Virus Proteins
Letters in Drug Design & Discovery 21, 3169 (2024); https://doi.org/10.2174/0115701808260478231023080842
/content/journals/lddd/10.2174/0115701808260478231023080842
/content/journals/lddd/10.2174/0115701808260478231023080842
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  • Article Type:     Research Article
Keyword(s): bioinformatics; intrinsic disorder predisposition; MPOX; MPOX gene; MPOX mutant proteins; polarity index method profile; structural proteomics

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