Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 22, Issue 7, 2022

More than 200 viruses infect humans, but treatments are available for less than ten of them. To narrow the gap between ‘bugs and drugs,’ a paradigm shift is required. The “one drug, one bug” approach can be expanded to a “one drug, multiple bugs” strategy such that the host’s defense system is targeted rather than the virus. Viral superinfection therapy (SIT) activates interferon genes’ natural, antiviral defense system Read More

Since the advent of the COVID-19 pandemic in 2019, a mammoth research activity targeting the etiological features of COVID-19 has commenced. Many aspects of the disease have been studied, and various others are under consideration. The secondary microbial coinfections with COVID-19 have generated some serious concerns across the globe. This review mainly focuses on the notable secondary coinfections. The coinfec Read More

Over two years after the start of the SARS-CoV-2 epidemic, which has demised over 5 million people, the world is still on high COVID-19 alert in February 2022, and new variants are emerging. Since January 2020, the World Health Organization (WHO) has been closely monitoring and analyzing the evolution of SARS-CoV-2 in partnership with national authorities, public health organizations, and scientists. To prioritize glo Read More

Epigenetics is related to the various pathways that show long128;term impacts on the gene expression patterns without alterations in nucleotide sequences. Over the last decade, epigenetics advanced significantly in the science of biology, oncology, innate immunity as well as pathogens and infectious diseases. In the present paper, we aimed to review the relationships between COVID-19 and epigenetic alterations of the infe Read More

Backgrounds: SARS-CoV-2 infection typically presents with fever and respiratory symptoms. Besides this, COVID-19-related central and peripheral nervous system manifestations are emerging. Objectives: This study summarises the demographics, clinical profiles, laboratory findings, management strategies, and outcomes in a large number of patients with COVID-19-related GBS and its variants. We also compared its Read More

Backgrounds & Aim: Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome caused by Coronavirus. Knowledge of the fate of infection and risk factors among health care workers is essential to enforce special infection control measures. We aimed to determine the percentage of COVID-19 infection and the associated risk factors as well as the predictors of COVID- 19 among health care workers in A Read More

Background: Fourier Transform Infrared (FTIR) spectroscopy and reverse phase highperformance liquid chromatography, RP-HPLC analysis have been used for the quantitative determination of local l commercially available Pitavastatin products. Methods: The FTIR method of analysis is not widely used in pharmaceutical quality control laboratories. This technique is non-destructive, reliable, precise, and efficient, and the sam Read More

Background: The presence of the class I integron gene is associated with the emergence of multiple drug resistance (MDR) phenotype in Pseudomonas aeruginosa (P. aeruginosa) isolates. Aim: The objectives of this research were to study the prevalence of integrase genes I (Intel I) and integrase genes II (Intel II) in clinical isolates of P. aeruginosa and its association with antibiotic resistance in these isolates. Methods: Read More

Background: In immuno-compromised organ transplant recipients, toxoplasmosis can be caused by either an infected graft or a latent infection, during which transformation from a chronic state to an active infection (reactivation) is observed. PCR is an accurate and sensitive molecular method widely used in medical sciences, especially in diagnostic procedures. Objective: The aim of this study was to determine the prev Read More

Mucormycosis, also known as "black fungus," is a potentially fatal disorder that causes blurred or double vision, chest pain, and breathing problems. The introduction of novel risk factors and causative agents, as well as the problems with controlling the disease, are all significant problems with mucormycosis in India. It is most common among COVID-19 patients. Mucormycosis is an invasive fungal disease that primarily affects i Read More

Superantigens (Sags) are a part of some viral or bacterial proteins that stimulate T cells and antigen-presenting cells leading to systemic immune repose and inflammation. SAgs might have a possible role in various inflammatory childhood diseases (e.g., Kawasaki disease, atopic dermatitis, and chronic rhinosinusitis). Worldwide studies have been conducted to determine the role of staphylococcal SAgs (TSST-1) in various infl Read More

SARS-CoV-2 was reported as the cause of coronavirus disease 2019 (COVID-19) in late December 2019. According to sequencing and phylogenetic studies, the new virus belongs to Coronaviridae family and Betacoronavirus genus. Genomic sequence analysis has shown SARS-CoV-2 to be similar to SARS. SARS-CoV-2 is more infectious, and the high level of COVID-19 community transmission has led to a growing pandemic. Althou Read More