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- Volume 22, Issue 4, 2022
Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 22, Issue 4, 2022
Volume 22, Issue 4, 2022
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Challenges in Engendering Herd Immunity to SARS-CoV-2 Infection: Possibly Impossible But Plausibile
Authors: Sukhes Mukherjee and Suman K. RayHerd immunity can only be achieved when it is extended to the population level. When a sufficiently significant fraction of immune individuals exists in a group, it confers indirect protection from infection to vulnerable individuals. This population-level effect is frequently considered in the context of vaccination programs, which attempt to build herd immunity so that people who cannot be vaccinated, such as the very young or tho Read More
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Third Wave of the COVID-19 Pandemic: Prominence of Initial Public Health Interference
Authors: Sukhes Mukherjee and Suman K. RaySince the first news of a coronavirus-related pneumonia outbreak in December 2019, the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which causes COVID-19, has spread worldwide, with more than 100 million people infected in over 210 countries and two million deaths. In the UK (B.1.1.7), South Africa (B.1.351), Brazil (P.1), and India (B.1.617), independent SARS-CoV-2 lineages have recently been Read More
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In silico ADME/Pharmacokinetic and Target Prediction Studies of Ethambutol as Drug Molecule
Authors: Arnav A. Joshi, Sakshi V. Khairnar and Hemchandra K. ChaudhariBackground: The conventional approach for the development of any pharmaceutically active molecule is a time-consuming and costly process because the synthesis is followed by laboratory tests which are then followed by long clinical trials. Hence, a faster approach is desired. This article discusses Ethambutol, a frontline anti-tubercular drug that has its properties predicted by the SwissADME tool and the results would be c Read More
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Ivermectin in COVID-19 Management: What is the Current Evidence?
Authors: Madhavi Eerike, Gerard M. Raj, Rekha Priyadarshini, Gandham Ravi, Debasis Bisoi and Venu G. R. KondaIvermectin (IVM), an approved anthelminthic drug, has been reported to have antiviral, antibacterial, and anticancer activities. Antiviral activity is due to the inhibition of nuclear cargo importin (IMP) protein. The anti-SARS CoV-2 activity through in vitro study was first reported by an Australian team. Later, many studies were conducted, and most of the study results were available as non-peer-reviewed preprints. In this narrativ Read More
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Nipah Virus: An Updated Review and Emerging Challenges
Authors: Mohamed D. Gabra, Hazem S. Ghaith and Mahmoud Ahmed EbadaMany hospitals are teetering on the edge of being overwhelmed, with many already there because of the COVID-19 pandemic. Moreover, a recent report has also warned about the Nipah virus (NiV). NiV is a pleomorphic enveloped virus that belongs to the Paramyxoviridae family (genus Henipavirus); it affects both the respiratory and central nervous systems, with a fatality rate ranging from 40% to 75%, as documented Read More
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Breast Cancer Risk and Human Papillomavirus Infection: A Bradford Hill Criteria Based Evaluation
Background: The association between human papillomavirus (HPV) and human breast cancer (BC) has already been thoroughly studied worldwide with contradictory findings. Although the researchers have tried to minimize the conflict using statistical meta-analysis because of its shortcomings, there is still a need to evaluate the correlation between HPV and BC using any additional method. Objectives: This study was launched to Read More
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Technology in the Era of COVID-19: A Systematic Review of Current Evidence
Background: During the COVID-19 pandemic, the use of technology-based services has been incremental by the care providers for patients scheduling, regulatory considerations, resource allocation, thus enabling virus exposure prevention while maintaining effective patient care. This study aims to review the currently available evidence to identify available technology solutions in the era of COVID-19. Methods: A syste Read More
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Promising New Antimalarial Combination Drugs: Garlic and Arteether in Pregnant Mice Infected with Plasmodium berghei
Authors: Vathsala P. Govindan and Krishna Murthy PurushothamaBackground: Antimalarial prescription remains a challenge in pregnant women because of maternal and fetal complications. Recently, garlic and α-β-arteether combination treatment in malariainfected mice conferred protection. The purpose of this study is to evaluate the efficacy of these drugs during malaria in pregnancy and its safety measures. Objective: The study evaluates the efficacy of arteether and garlic combinat Read More
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Vaginal States: Detection of Conversion Processes in Women Using Contraception and Characterization of Vaginal Lactobacillus Species
Background: The vaginal microenvironment, regulated by an immune system, can be protected or altered by many factors, including contraceptive methods. Objective: The objective of this study is to evaluate the impact of contraceptive methods on the basic vaginal states (BVSs) and to identify culturable vaginal Lactobacillus species. Methods: This is a prospective, consecutive, longitudinal, and descriptive study. The vaginal cont Read More
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A Case of Multiple Sclerosis with Protracted Course of COVID-19
Authors: Mehrdad Hasibi, Marjan Asadollahi and Ali Asadollahi-AminBackground: We reported a case of multiple sclerosis (MS) with persistent symptomatic COVID-19, which was complicated by new-appearing severe pneumonia 40 days after disease onset. Case Presentation: A 38-year-old man with a history of multiple sclerosis referred to our hospital with fever, shaking chills, cough, and dyspnea. In his history, the patient had developed mild COVID-19 from 40 days ago. After 7 days of dise Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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