Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Current Issue

It is a known fact that HIV infection remains a serious public health problem throughout the world, and the need to constantly develop new antiretroviral drugs to combat HIV emerges from the fact that repetitive mutations occurring in viral enzymes make this virus resistant to antiretroviral drugs. This resistance causes failure of treatment, and hence, for many years, extensive research has been to discover ne Read More

The pink eye outbreak in 2023 was caused due to humid weather conditions in most regions of India. The most affected states include Delhi, Gujrat (21% cases), Maharashtra (30%), Himachal Pradesh (4%) and Karnataka (4%). The epidemiological data indicates that males have a high prevalence rate as compared to females; urban areas were most affected, and professionals as well as students were the population gr Read More

Pimples, blackheads, whiteheads, etc., are common types of acne that pop up on the skin each time, whenever dead cells and oils obstruct the outgrowth of hair from the hair follicle. It is very common to observe this condition in teenagers, but regardless of age, if the causing condition is met, acne can occur at any point in life. The characteristic feature of all types of acne is it starts with inflammation of the skin. These inf Read More

Mitochondria, also called ‘powerhouse of the cell’, is meant for energy generation in eukaryotic cells. This action is performed by mitochondria through the oxidative phosphorylation (OXPHOS) of the respiratory chain (RC). Based on the functioning of the cell, the number of mitochondria varies up to thousands in number. Mutations in the mitochondrial DNA (mtDNA) and/or nuclear DNA (nDNA) genes may lead to the gene Read More

BackgroundSNP based association studies have revolutionized the field of biomedicines. Enteric fever is a systemic disease with etiologic agent Salmonella enterica serovar typhi and paratyphi. It is a serious health issue worldwide and presents wide variations in incidence, rates, and severity. Previous investigations revealed that genetic variations may lead to susceptibility to typhoid fever. The current study was performed to i Read More

Hygiene has been identified as an important step in anticipating health-related pollution, with conflicting reports about consistent sanitation standards in the nation. This narrative review of published studies has led to the discussion of hand hygiene and health practices, as well as the identification of necessary methods that are available in low and middle-income countries. An effective survey of accessible information Read More

BackgroundClostridium difficile is an opportunistic infection that can lead to antibiotic-associated diarrhea and toxic megacolon.ObjectiveThis systematic review study aimed to investigate polyphenols' antibacterial and anti-toxin properties and their effects on reducing complications related to C. difficile Infections (CDI).MethodsThis systematic review was conducted following the PRISMA guideline 2020. Multiple databases, inc Read More

BackgroundThe alarming increase in antibiotic resistance urges alternative and efficacious antimicrobial solutions. Historically, medicinal plants have been used for therapeutic purposes, such as relieving pain and healing wounds. The evaluation of the natural therapeutic effects of medicinal plants in a manner that resembles how humans typically consume them is lacking. In this study, many medicinal plants known to have s Read More

BackgroundToxoplasmosis is a cosmopolitan infectious disease in warm-blooded mammals that poses a serious worldwide threat due to the lack of effective medications and vaccines.AimsThe purpose of this study was to design a multi-epitope vaccine using several bioinformatics approaches against the antigens of Toxoplasma gondii (T. gondii).MethodsThree proteins of T. gondii, including ROP18, MIC4, and SAG1 were analyze Read More

BackgroundTuberculosis is an infectious disease caused by Mycobacterium tuberculosis. The current treatment protocols for pulmonary tuberculosis are quite effective, even though the treatment requires 3-6 months. The current treatment protocols for extrapulmonary tuberculosis are based on the same drugs that are used for pulmonary tuberculosis. However, the success rates are much lower for certain types of Read More

ObjectiveThe current study aimed to formulate and evaluate herbal gels containing essential oils for the treatment of infection caused by microbial species, i.e., S. aureus, E. coli, P. aeruginosa, and B. subtilis. These species are also responsible for acne directly and indirectly.Material and MethodsThe gels were prepared using a gelling agent with 1% Carbopol-940, and they were further evaluated for physical appearance, Read More