Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 22, Issue 2, 2022

Numerous observational, epidemiologic data have suggested that the risk of COVID19 is related to shared meals or drinks. The presence of ACE2 receptors in the gastrointestinal tract supports this hypothesis. Furthermore, several patients experience gastrointestinal symptoms without any respiratory disease. The SARS-CoV-2 found on food and packaging in China and the epidemic resurgence attributed to foods are also str Read More

Coronavirus disease 2019 (COVID-19) is a serious viral disease caused by SARS-CoV-2, associated with high morbidity and mortality, and represents a significant public health crisis worldwide. Despite recent efforts for developing novel antiviral agents, no specific drugs are approved for the management and treatment of COVID-19. The immune responses to viral infection followed by cytokine storm and acute respiratory dis Read More

Purpose: This paper aims to review clinical and preclinical evidence regarding new strategies for the prevention of vancomycin-induced nephrotoxicity. Methods: Evidence from 2014 to the end of 2019 was included. Twelve animal studies and one clinical trial were evaluated. Results: Although the incidence of vancomycin-induced nephrotoxicity was not reduced significantly in the clinical trial, antioxidants reduced the i Read More

Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb), infects the lungs' alveolar surfaces through aerosol droplets. At this stage, the disease progression may have many consequences, determined primarily by the reactions of the human immune system. However, one approach will be to more actively integrate the immune system, especially the pattern recognition receptor (PRR) system Read More

Background: In the rural areas of sub-Saharan African regions, skin diseases are so common. Due to which the population of the sub-Saharan region suffers from different types of skin disorders. In these regions, many treatment options are not available for the treatment of skin disease. Aim: The current study aims to discuss various skin diseases and their treatment strategies, specifically in sub-Saharan African regions. Read More

Certain infectious diseases are more common in infants than any other age groups and are associated with morbidities in childhood and adulthood, and even mortality in severe cases. Environment, epidemic and maternal immunity are the main causes of these infections. Early diagnosis using molecular methods and treatment is therefore important to prevent future complications. Vaccines are recommended during infancy a Read More

Introduction: Many potential vaccines for COVID-19 are being studied and developed. Several studies have reported on the safety and efficacy of these vaccines. This systematic review aimed to report on the current evidence concerning the feasibility and effectiveness of vaccines for COVID-19. Methods: A systematic search was carried out utilizing the keywords in the online databases, including Scopus, Web of Science, Pub Read More

Background: An increase in resistant gram-positive cocci, especially enterococci, requires an epidemiologic re-assay and its results may affect empirical treatments for these infections. Objective: In this study, we investigated the microbial epidemiology and resistance pattern of enterococcal bacteremia. Methods: This study was a cross-sectional study that investigated all cases of positive blood cultures with Ente Read More

Introduction/Background: Coccidioidomycosis is a fungal infection that is a rare cause of prosthetic joint infection (PJI) in patients. Case Presentation: This case report describes an immunocompetent patient who had a right total hip arthroplasty (THA) complicated with Coccidioidomycosis. This patient is the 9th reported case of Coccidioidomycosis, causing a PJI and only the second case to be reported i Read More