Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 21, Issue 7, 2021

A successful viral infection is due to the effective evasion of viruses of the immune system. The entry of viruses is usually detected by different cellular receptors including PRRs. Recognition of the viral genome leads to the production of interferons through a signaling stream. This review article provides brief information regarding escape mechanisms of DNA and RNA viruses from the host immune system. These strategie Read More

A novel coronavirus, SARS- CoV-2 (2019-nCoV), emerged in December 2019 as an immediate global challenge. Comprehensive efforts at the present time are focused simultaneously on containing the spread of this virus and extenuating the ill effects. There is an immediate need for drugs that can help before a vaccine can be developed. Researchers are endeavoring to find antiviral therapies specific to the virus. As the co Read More

The Covid-19 pandemic has become a major challenge for health care professionals and researchers all over the world. The discovery and development of new drugs require time for passing the quality, safety, and efficacy criteria. Hence the only available option is to rely on herbal or natural remedies as well as other existing ones. Nature has its healing power and has the remedy for all the ailments from which life on Read More

Recently, novel coronavirus infection (COVID-19) emerged in Wuhan, China has been declared as pandemic by WHO. Until now, no evidence is documented regarding its wild animal reservoir or intermediary host, but, human-to-human transmission, asymptomatic carriers were very much observed. The number of confirmed cases and death toll have been increased almost all over the world indicating its potential threat to Read More

Background: Coronavirus disease 2019 (COVID-19) is a life intimidating viral infection caused by a positive sense RNA virus belonging to the Coronaviridae family, named severe acute respiratory distress syndrome coronavirus 2 (SARA-CoV-2). Since its outbreak in December 2019, the pandemic has spread to more than 200 countries, infected more than 26 million, and claimed the lives of more than 800,000 people. As Read More

Background: H1N1 is known to cause periodic seasonal flu in the Indian subcontinent since 2009. The clinical course and the underlying immunity of the host contribute to the development of secondary bacterial infections in the infected patients. Objectives: This study aims to analyze the secondary bacterial infections in confirmed H1N1 cases admitted in our hospital (from 2015 to 2018) with respect to the comorbidities, Read More

Background: Helicobacter pylori infection is identified as a major cause of stomach ulcers, chronic inflammation and gastric cancer in hemodialysis patients. Dialysis also leads to changes in the composition and flow of saliva. Objective: The aim of this study was to investigate the salivary Helicobacter pylori infection, Calcium, Urea, pH and flow rate in hemodialysis patients in comparison to the healthy control group. Metho Read More

Background: Antibiotics are known to be effective in treating bacterial infectious disease. Changes in microflora and mucosal dysbiosis may take place after antibiotic treatment. We investigated in this research the effect of anti-Helicobacter pylori treatment (AHT) on local immunity of the female genital tract. Methods: The study identified the levels of cytokines IL-8 and TNF-α in vaginal secretion in a group of female patien Read More

Background: Serratia spp. is a common enteric bacterium generally thought not to be pathogenic in the gastrointestinal tract. Serratia marcescens is a member of the genus Serratia, which is a part of the family Enterobacteriales. Of all Serratia species, S. marcescens is the most common clinical isolate and the most important human pathogen. Objective: We discuss here four cases of Serratia marcescens which were repo Read More

Background: Staphylococcus haemolyticus is one of the most frequently coagulasenegative staphylococci isolated from healthcare-associated infections, mainly those related to implanted medical devices. Objectives: This study aimed to determine the antimicrobial susceptibility profile and biofilm forming capacity of S. haemolyticus isolated from bloodstream infections. Methods: A total of 40 S. haemolyticus isolates were c Read More

Background: West Nile virus (WNV) is a positive-sense single-stranded RNA virus of the family Flaviviridae and genus Flavivirus. The virus is transmitted primarily by the bite of Culex species mosquito and is of global concern. The infection is associated with a wide spectrum of signs and symptoms and is more fatal in the elderly, infants, and immunocompromised individuals. Case Presentation: We report a case of WNV Read More

Background: Since December 2019, there has been an increasing number of patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world. As of March 2020, the World Health Organization declared a global pandemic. Case Presentation: To our best knowledge, this is the first report of a patient with SARS-CoV-2 infection presenting with constrictive pericarditis, possibly from t Read More