Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 17, Issue 1, 2017

Background: Zika virus (ZIKV) is a deadly flavivirus that has spread from Africa to Asia and European countries. The virus is associated with other viruses in the same genus or family, transmitted by the same mosquito species with known history of fatality. A sudden increase in the rate of infection from ZIKV has made it a global health concern, which necessitates close symptom monitoring, enhancing treatment options, a Read More

Background: The pattern of Mycobacterium tuberculosis susceptibility to first line drugs and multidrug resistance in Al-Madinah Al-Munawarah, a seasonally overcrowded are during Hajj and Omrah, is not well studied. Objective: This study aimed to investigate anti-tuberculosis drug resistance and its distribution among new cases in Al-Madinah Al-Monawarah. Methods: Study subjects included 622 patients with first time confirm Read More

Chronic hepatitis B is a major global health issue, and has no known cure. Currently there are over 240 million people infected with the disease, and it leads to the death of over 686,000 people each year. A total of seven treatments which help to control the disease are currently available: interferon-based treatments (pegasys, and interferon alpha), and nucleoside and nucleotide analogs (Viread, Baraclude, Tyzeka, Hepser Read More

Background: Use of intra-articular antibiotics for the treatment of arthroplasty infections has gained some interest over the last few years. Objective: Some data exists on its use with bacterial arthroplasty infections. Method: We used intra-articular amphotericin B in an attempt to cure these joint infections and perform a one stage revision. Results: Two patients were treated with intra-articular amphotericin B for 6 week Read More

Background: Echocardiography is a reliable means for the diagnosis of functional and valvular diseases of the heart in HIV positive and HIV negative patients. The current study was to evaluate echocardiographic abnormalities in HIV positive patients under an antiretroviral therapy (ART) program in Tehran, Imam Khomeini Hospital, Iran. Methods: This is a descriptive cross-sectional study, conducted among 231 HIV-1 posit Read More

Background: Arthritis could be caused by different etiologies ranging from rheumatologic diseases to infectious conditions. Therefore, early diagnosis of etiology and treatment is important. The purpose of this study was to determine the the M. pneumonia in synovial fluid of children with arthritis by 2 methods (serology and qualitative PCR). Methods & Materials: This trial was carried out as a cross sectional study in pediatr Read More

Bacteremia is frequently caused by gram-positive organisms such as Staphylococcus aureus or β hemolytic streptococci. While there is adequate information for the diagnosis and management of these common bacteria, less information is available to address bacteremia that is caused by uncommon bacteria such as Citrobacter. Citrobacter species are gram-negative bacilli that have been noted to cause infections in immu Read More

Background: Neisseria are usually harmless inhabitants of otherwise asymptomatic persons’ upper respiratory mucosal surfaces. Method: It is, therefore, expected that a disturbance in the physiology leads to nongonococcal, non-meningococcal Neisseria becoming pathogenic. Result: We report the case of a diabetic man who initially presented with nonspecific symptoms and was later found to have cystitis caused by N. or Read More

Methicillin resistant Staphylococcus aureus (MRSA) is responsible for a large number of antibiotic resistant infections worldwide. Understanding the epidemiology and identifying the molecular characteristics of MRSA is elemental in designing infection control plans to minimize the risks associated with these infections. The prevalence of MRSA varies between the different geographic regions. In Egypt, such knowledge is sparse, with Read More