Use of Intra-Articular Amphotericin B in the Treatment of Candida parasilosis and albicans in Prosthetic Joint Infections (PJI): A Novel Approach to this Difficult Problem

Background: Use of intra-articular antibiotics for the treatment of arthroplasty infections has gained some interest over the last few years. Objective: Some data exists on its use with bacterial arthroplasty infections. Method: We used intra-articular amphotericin B in an attempt to cure these joint infections and perform a one stage revision. Results: Two patients were treated with intra-articular amphotericin B for 6 weeks followed by suppressive fluconazole for 4 months. Intra-articular joint fluid was cultured during this process for re-growth of fungus. Conclusion: Both patients were treated successfully with the method with follow up showing no evidence of recurrence. IA administration of amphotericin B may be an alternative treatment in these patients.