Drug Delivery Letters - Volume 6, Issue 2, 2016

Background and Objectives: The aim of present study was to prepare quetiapine fumarate (QF) loaded NE and mucoadhesive NE to enhance the uptake of QF to brain via intranasal (i.n.) delivery. Method: On the basis of solubility studies capmul MCM was selected as the oily phase. The NE was optimized using response surface methodology. A numerical optimization technique was employed to determine the optimal values of v Read More

Background: This research effort was aimed for the use of edible natural polymers from Dillenia indica and Bora rice for the preparation of palatable dry syrup containing bitter drugs Norfloxacin and Tinidazole for paediatric use. Methods: Bora rice flour and the mucilage extracted from Dillenia indica were characterised by UV and FTIR. They were also evaluated for safety. Norfloxacin-Tinidazole loaded microspheres wer Read More

Background: Controlled transdermal delivery system for vildagliptin is potentially useful in improving the clinical efficacy and reducing the incidence of adverse side effects. The objective of this study was to develop an adhesive transdermal system for the delivery of vildagliptin. Methods: Vildagliptin-incorporated adhesive patches (P1-P10) were formulated on a polyester-release liner, and laminated with polyethylene-backi Read More

Background: Microwave assisted grafting of natural materials enables their use for specific drug delivery application. Microwave assisted reactions have numerous advantages like rapid reactions, improved yields, high purity products, simple, safe, efficient and ease of scale up. Methods: In the present study graft copolymers of n-vinyl-2-pyrrolidone and locust bean gum were prepared by microwave assisted graft copolymerizati Read More

Background: Flunarizine Dihydrochloride (FDC) is used as a Prophylaxis to a migraine. It has solubility issues and it is practically insoluble in water and alcohol. FDC is widely prescribed for a migraine which is available in the form of tablets, and capsules. It is advantageous to deliver FDC as a nasal drug delivery system in the form of the nanoemulsion. Nanoemulsion increases the solubility of the poorly soluble drug as well as i Read More

Purpose: The genetic makeup of each individual varies among each other and has changed the pharmacokinetics. Thus, pharmacokinetics of every region has variations, due to the changes in genetic expression of various genes. Allopurinol inhibited xanthine oxidase that declined the uric acid from body. The pattern for pharmacokinetics of allopurinol in Pakistani males was calculated and the bioequivalence was compared for t Read More

Background: Previously, we demonstrated a similar adsorption of the vaccine candidate TERAVAC against HIV-1 to the aluminum hydroxide and aluminum phosphate adjuvants but the subcutaneous administration with aluminum hydroxide promoted a better Th1 response than the aluminum phosphate. Objective: The present study examined whether a differential three-dimensional (3D) adsorption of the multiantigenic formul Read More

Background: Tamoxifen (TMX) has been in clinical use for over 40 years and can be considered the standard for breast cancer chemoprevention in high-risk patients. Unfortunately, patient compliance to treatment is low due to systemic toxicity. Objective: The present study demonstrates the use of a nanochannel Delivery System (nDS) for controlled and sustained local release of TMX in mammary tissue. Method: TMX release Read More