Drug Delivery Letters - Volume 6, Issue 1, 2016

Nitric oxide (NO) has a multitude of biological activities and has great potential for numerous therapeutic applications. However, its small size, short halflife and instability under physiological conditions make achieving therapeutic levels challenging. Nanoparticle carriers offer potential to overcome the various physiochemical and biological challenges for effective NO delivery. State of the art in the development and applic Read More

Background: Oral drug administration is preferred by most patients; however this is a challenge for the majority of chemotherapeutic agents that are required to be given via injection, due to their unfavourable physiochemical and biopharmaceutical properties. A silica-lipid hybrid (SLH) carrier formulation has been developed to overcome the water solubility-limited oral absorption of SN-38 and to advance its clinical application Read More

Pressurised metered dose inhalers (pMDI) are still the most heavily prescribed medicines for the treatment of asthma. Various add-on devices are made available through pharmacies either on prescription, over-the-counter or off-theshelf. These include actuation aids, spacers and alternative actuators. The Sports- Haler™ is a replacement actuator for the conventional Ventolin™ actuator and offers a compact and colourful alt Read More

Background: Blepharitis is considered one of the most common ocular surface conditions in optometry and ophthalmology practice. While azithromycin and dexamethasone have been used successfully to treat blepharitis, they are generally formulated as eye drops requiring frequent administration. Ocular inserts based on biodegradable polymers may overcome some of the problems associated with conventional eye Read More

In April 2014, the World Health Organization announced the beginning of a post-antibiotic era and declared antimicrobial resistance (AMR) a public health priority demanding global action. If no action is taken, by 2050 AMR will kill more people each year than cancer, with 10 million estimated annual deaths at a cost of $100 trillion to the global economy. New therapies to tackle multidrug resistant bacterial pathogens are urgen Read More

Background and Objective: Many recent studies have focused on the development of methods to overcome the barriers faced by oral drug delivery. This study describes the synthesis of three glycolipid-based drug delivery systems designed to be associated with charged drugs to improve their oral bioavailability. Methods: D-Glucose was used as a scaffold to construct charged glycolipids with anionic and/or cationic Read More

Non-melanoma skin cancers are among the most commonly diagnosed skin cancers in the world. Ultraviolet radiation is a primary carcinogen resulting in UV induced mutations, loss of activity in tumour suppressor genes and the over expression of oncogenes in keratinocytes resulting in the development of skin malignancies. With the continued rising rate of non-melanoma skin cancer, topical therapies have become an e Read More

Background: There is significant interest in the development of oral vaccine delivery systems, with the opportunity to access the body’s immune system. Recently, the use of multi-compartmental systems to deliver vaccines has been investigated. Objective: Here, we report on the development of a lipid-based multicompartmental system for oral vaccine delivery. Specifically, the system is based on a water-in-oil-in- Read More