Current Topics in Medicinal Chemistry - Volume 23, Issue 4, 2023

Physical injuries in sports are unavoidable, but they can be mitigated and even treated by using molecular hydrogen, which can be administered via a specially formulated sunscreen. The photocatalysts are a special class of semiconductors that can absorb a specific spectrum of light to promote its electron from the valance band (VB) to the conduction band (CB). This creates positively charged holes at VB and negatively charged Read More

Background: Since the emergence of HSV resistant strains, new antiviral agents have emerged and still are urgently needed, especially those with alternative targets. Objective: In this work, we evaluated new quinolone derivatives as anti-HSV. Methods: For this study, cells were infected and treated with different components to evaluate the profile of HSV replication in vitro. In addition, studies were performed to determine th Read More

Background: Cancer is one of the most important barriers to increasing life expectancy in all countries in the 21st century. Investigations of new anti-cancer drugs with low side effects are an urgent demand for medicinal chemists. Considering the known antitumor and immunomodulatory activity of thiazoles, this work presents the synthesis and antineoplastic activity of new thiazoles. Methods: The 22 new compounds (2a-v Read More

Engineered nanostructures of mixed transition metal sulfides have emerged as promising nanomaterials (NMs) for various electrochemical sensors and biosensors applications, including glucose sensors (GS) and lactic acid sensors (LAS) in clinical aspects. Electrochemical sensors based on nanostructured materials, such as transition metal sulfides and their nanocomposites, including graphene, carbon nanotubes, molecular Read More

Determining the amount of medication used is essential for correctly managing treatment systems. The unauthorized use of drugs and the importance of determining the absorbed and required dose of drugs in target organs are essential factors that justify the design of new drug monitoring systems. Electrochemical sensors and biosensors based on nanomaterials have been developed for drug monitoring in the p Read More

The binding of the therapeutic agents to the nucleic acids is one of the paramount issues in the drug development area that is studied by various techniques. Electrochemical studies have a big portion in this area due to the fact that they allow designing of novel monitoring systems that have superior properties such as being feasible and sustainable. These electrochemical monitoring tools analyze these interactions in in vitro Read More