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image of Antibacterial, Antibiotic-Potentiating, and Antiviral Activities of Selected Endemic Primary Rainforest Plants of Peninsular Malaysia
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Abstract

Background

There is a need to identify original molecules to develop drugs for the treatment of microbial infections. Such chemical entities could be found in secondary metabolites of rainforest plants that are not so well-known. This study examines the antibacterial and antibiotic-potentiating effects, and antiviral activities of six rainforest plants endemic to the primary rainforest of Malaysia.

Methods

Leaves, bark, fruits, and wood of , , , , , and were extracted successively with hexane, chloroform, and methanol, and tested against six human pathogenic bacteria species by disc diffusion and broth microdilution. The extracts were tested against influenza virus A/Puerto Rico/8/34 (H1N1) using MDCK cells.

Results

Of the 42 extracts tested, the hexane extract of fruits of inhibited the growth of with the MIC value of 39 µg/mL. The chloroform extract of leaves of potentiated the activity of levofloxacin against . The strongest antiviral activity was observed with the chloroform extract of leaves of with the IC value of 6.3 µg/mL. The chloroform extract of bark of with the IC value of 0.6 µg/mL was the most cytotoxic.

Conclusion

Preserving the primary rainforest of Malaysia is a means to preserve natural products with the ability to be developed as antimicrobial leads. In particular, , , and could be examined for their active antimicrobial constituents.

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© 2024 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2025-02-20
2025-04-16

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Antibacterial, Antibiotic-Potentiating, and Antiviral Activities of Selected Endemic Primary Rainforest Plants of Peninsular Malaysia
Bentham Science Publishers ; https://doi.org/10.2174/0122150838298401240924105857
/content/journals/ctm/10.2174/0122150838298401240924105857
/content/journals/ctm/10.2174/0122150838298401240924105857
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  • Article Type:     Research Article
Keywords: Knema retusa ; Litsea spathacea ; Diospyros hasseltii ; antiviral ; Burkillanthus malaccensis ; Cleistanthus bracteosus ; Kibatalia maingayi ; antibiotic potentiator ; Antibacterial

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