Current Signal Transduction Therapy - Volume 9, Issue 3, 2014

Hypoxia inducible factor-1α is an important transcription factor which is necessary for hypoxic gene expression that responds to changes in oxygen level in cell. HIF-1α remained stable and active in the occurance of Fe2+ and oxygen but it is depleted through the Von Hippel Lindau protein (pVHL) or Ubiquitin or Proteosome pathway. Restriction of oxygen induces inhibition of prolyl hydroxylase and accumulation of HIF-1α which in t Read More

Lung cancer is a global public health concern with the highest morbidity and mortality among all cancers. Biomarkers can be used for early lung cancer detection, prognostication and optimal treatment. Research on biomarkers will enable more effective therapy for each individual patient. Great progress has been made in biomarker discovery with more understanding involved in lung cancer. Lung cancer biomarkers can be Read More

In the last several years, bone tumor related microRNA research showed an explosive growth. MicroRNA was found to have a high or low expression level in bone tumor tissue and some microRNAs proved to be the biomarker for poor prognosis. The majority of research was focused on osteosarcoma and Ewing sarcoma. Many tumor associated molecules, including oncogenes and tumor suppressor genes, were found Read More

Coronary artery disease (CAD) is a type of heart disease with high incidence and mortality in Europe and the United States as well as in Asian countries. miRNA is a kind of regulatory RNA which controls gene expression by binding to complementary sequences of their targets, thus promotes RNA degradation and/or inhibits protein translation. Recent studies showed miRNAs function as key mediators in the pathologi Read More

Sleep is a vital segment of life, however, the mechanisms of diet promoting sleep are unclear and are the focus of research. Insomnia is a general sleep disorder and functional foods are known to play a key role in the prevention of insomnia. A number of studies have demonstrated that major insomnia risk factors in human being are less functional foods in dietary. There are higher functional components in functional foods pro Read More

Background: Pancreatic cancer is characterized by severe hypoxic regions, and in order to survive and proliferate under such adverse tumor microenvironment with limited supplies of nutrients and oxygen, pancreatic cancer cells must rely on their ability to reprogram canonical metabolic pathways. Thus, the understanding of pancreatic cellular metabolic transformation could shed light on the discovery of novel therapeuti Read More

Background: This study aimed to compare the improvement in the quality of life (QoL) in the long-term follow-up of 12 to 24 months after transcatheter aortic valve implantation (TAVI) therapy for old people with severe aortic stenosis. Methods: According to the guidelines provided by PRISMA, published studies till 15 June, 2014 were retrieved from Google Scholar, Pubmed, Embase and CNKI. Health-related QoL was ev Read More