Current Signal Transduction Therapy - Volume 18, Issue 3, 2023

Background: Depression is one of the leading causes of disability around the globe. In the early years of depression, it is hypothesized that neurotransmitters have a major or dominant role in depression pathophysiology. The roles of different parts of the brain and neurotransmitters have emerged at different intervals of time, and various hypotheses beyond monoamines have arisen. In this review, numerous theories Read More

Background: When analyzing multivariate data, it can be challenging to quantify and pinpoint relationships between a collection of consistent characteristics. Reliable computational prediction of cancer patient's response to treatment based on their clinical and molecular profiles is essential in this era of precision medicine. This is essential in helping doctors choose the least contaminated and most potent restorative Read More

Background: High or abnormal blood sugar levels are the hallmark of diabetes mellitus (DM), a metabolic disorder that will be one of the major causes of mortality in 2021. SGLT2 inhibitors have recently shown beneficial effects in the treatment of diabetes by reducing hyperglycemia and glucosuria.Objective: Molecular docking and ADMET studies of Schiff base- based 1, 3, 4-thiadiazole scaffold as SGLT2 inhibitors.Methods Read More

Epilepsy is a neurological disorder characterized by spontaneously occurring seizures known for several decades. Despite the availability of current anti-epileptic drugs, including Phenytoin, Valproate, Carbamazepine, Lamotrigine, Gabapentin, Vigabatrin, etc., a considerable 30% of the epileptic population are drug-resistant to the available conventional medications. This suggests a need to find new drug therapy for the manage Read More

Cervical cancer is ranked as the fourth most frequently diagnosed cancer and the fourth leading cause of cancer-related deaths among females. Cervical cancer is a complex disease influenced by various genetic, epigenetic, and environmental factors. While treatment options such as radiotherapy, chemotherapy, and hormonal therapy exist, the prognosis remains poor due to high rates of distant and lymphatic metast Read More