Current Signal Transduction Therapy - Volume 12, Issue 2, 2017

Background: Transforming growth factor beta (TGF-β) is a multifunctional protein that acts as a regulator of cellular function such as proliferation, migration, differentiation, apoptosis, vascular hemostasis, and development of organisms. As the TGF-β is the key player of cell proliferation and apoptosis it also involves in different diseases such as autoimmune disorder and vascular disease. The TGF-β signaling pathway starts wi Read More

Background: Inflammatory Bowel Disease (IBD) is the hypernym of a group of chronic inflammatory relapsing gastrointestinal diseases which consist of ulcerative colitis (UC) and Crohn's disease. Although its etiology is ambiguous; it is marked by the dysregulated production of proinflammatory mediators like tumor necrosis factor (TNF)-α and interleukins (IL) etc. These accelerated inflammatory responses are t Read More

Background: Failure of cell division control due to mutations leading to inactivation or over activation of regulatory proteins is the leading cause of cancer development. Several mitogens and growth factors have been found to regulate cancer cell cycle progression. However, all signalling pathways converge to the cell cycle machinery and thus disruption of cell cycle control offers an attractive therapeutic target for the tre Read More

Background: Targeting of virulence factors is considered as a novel strategy for antifungal drug development. We have tried to identify potential targets of Indole and Isatin in the Yeast to hyphal induction signal transduction pathways in the human pathogen Candida albicans. Objective: To study changes in gene expression during yeast to hyphal transition in the presence and absence of Indole and Isatin. Methods: Total RNA Read More

Background: Mastography is a strong screening and diagnostic tool for the primitive detection of cancer in the breasts. The acquired mammogram images or stored mammogram images are often corrupted by the outliers. These outliers must be eliminated before microcalcification. Method: In the proposed scenario, an adaptive filter that uses median of minimum distance from its neighbourhood is used to eliminate the salt an Read More

Background: Ubiquitous naturally occurring longitudinal magnetic waves may serve as a carrier for biological signal transfer. Material and Method: Scalar waves were generated by Meyl`s Experimental Scalar Wave Kit. An experimental model was developed to study the signal transfer of an antifungal drug to yeast colonies. Yeast colonies were cultivated on agar plates at a constant cultivation temperature of 28°C. Result and Read More