Current Signal Transduction Therapy - Volume 10, Issue 1, 2015

Osteoporosis was related with depression especially in patients treated with psychotropic medicine. Selective serotonin reuptake inhibitors (SSRIs), the first-line treatment of depression, could up-regulate the extracellular serotonin (5-HT) levels and affect the serotonin system in bone metabolism. 5-HT transporter5-HTT) knockout results in bone mass decreased, architecture altered and mechanical properties impaired Read More

The incidence of cancer is increased in patients with diabetes mellitus. Numerous epidemiological studies confirm this phenomenon, specifically with malignancies of the pancreas, liver, bile ducts, uterus, kidney, breast in postmenopausal women, colon, bladder and aggressive forms of prostate cancer. Disruption of homeostatic glucose metabolism may play a significant role in malignant cellular transformation and dise Read More

Recent studies have shown that there is an interaction between fat and bone metabolisms. Adipose tissue secretes leptin and adiponectin to regulate bone metabolism. Leptin inhibits bone formation by activating the sympathetic nervous system, whereas the peripheral pathway of leptin shows a positive effect on bone formation. Opposite to leptin, adiponectin enhances or inhibits bone formation osteoblast in the central Read More

Objective: To investigate the effects of the DNA methyltransferase inhibitor 5-Aza-2'- Deoxycytidine (5-Aza-Dc) on DLC-1 gene expression, methylation level, and the expression of downstream signaling molecules Cdc42 in the human multiple myeloma cell line RPMI8226 cells. Methods: The RPMI8226 cells were treated with 5-Aza-Dc, the methylation status of CpG island of DLC-1 gene was detected by bisulfate sequencin Read More

Objective: To explore the therapeutic methods on surgical repair of refractory pressure ulcers around hip and sacral region, and to conclude the focuses of the surgical treatment. Materials and Methods: From January 2007 to December 2013, tissue flap transport with vascular pedicle was applied to repair 77 cases refractory pressure ulcers (96 wounds) around hip sacral region, with the patients aging from 21 to 82. For th Read More

Background: Video-assisted thoracic surgery (VATS) provides a minimally invasive means to resect pulmonary nodules. However, small solitary pulmonary nodules (SPN) remain problematic during VATS owing to unpredictable visualization and palpation. Intraoperative small SPN localization provides a more obvious target to facilitate intraoperative resection. This study is a single-institution validation of intraoperative CT-guid Read More

The development of acute lung injury (ALI) is always accompanied by remarkably increased production of cytokines in plasma. However, the pathogenesis of this inflammatory response is unclear. In this study, the hypothesis whether Interleukin 33 (IL-33) is induced in the ALI patients and the possible mechanism was tested. The levels of IL-33 were found to be significantly induced in plasma of the ALI patients. Addition of I Read More

Background: Acute aortic syndrome (AAS) is a group of serious and lethal aortic emergencies, which have so variable and non-specific clinical presentations and can be misdiagnosed as other diseases. AAS occurs frequently in daily life, but too little attention was paid on the location of its vascular flap according to different daily activity patterns. Methods: The data of 160 cases hospitalized for non-traumatic acute aortic sy Read More

Objective: To investigate the mechanism of GITRL on regulating the inflammatory reaction through the programmed death ligand (PDL1) in Kupffer cells (KCs). Methods: The KCs and the T cells were isolated and divided into 6 groups: (1) the Control group; (2) LPS group; (3) LPS+Control siRNA group, transfected with Control siRNA; (4) LPS+GITRL siRNA group, transfected with GITRL siRNA; (5) LPS+pEGFP-N1 control plasmid gro Read More

Objective: To investigate the inhibitory effects and the mechanism of NF-ΚB decoy oligodeoxynucleotides (ODN) on Kupffer cells (KCs) activation. Methods: KCs were isolated and randomly divided into three groups: (1) a control group; (2) an LPS stimu1ation group and (3) an NF-ΚB decoy group, in which the KCs were transduced with an NF-ΚB decoy ODN prior to LPS stimulation. Following 6 hours of LPS stimulation, the NF Read More

Backgroud: Tsutsugamushi disease was really uncommon in the pediatric clinical. However, it can be quite severe, those who suffer them Tsutsugamushi disease can progress to multiple organ dysfunction syndrome (MODS) and hemophagocytic syndrome (HPS). Unfortunately, there were few reports on pulmonary hemorrhage caused by tsutsugamushi disease, especially in children. Because of the nonspecific clinical Read More