Current Radiopharmaceuticals - Volume 4, Issue 2, 2011

Molecular imaging, in particular positron emission tomography (PET), plays pivotal roles in 21st century personalized medicine. PET has been used in the clinic for decades and 18F-FDG has become indispensible in many facets of patient management, such as cancer staging and treatment monitoring. Commonly used PET tracers are typically labeled with 15O (t1/2: 122.2 s), 13N (t1/2: 10.0 min), 11C (t1/2: 20.4 min), or 18F ( Read More

The use of positron emission tomography (PET) for radionuclide imaging provides better sensitivity, better spatial and temporal resolution and better quantification accuracy in comparison with single photon emission computed tomography (SPECT). One limitation of PET is the predominant use of short-lived (with half-life up to 2 h) radionuclides. Extension of PET utility might be achieved by the use of more long-lived, “non-c Read More

This review gives a survey on the use and applications of technetium-94m (94mTc) as a non-conventional positron emission tomography (PET) radionuclide for molecular imaging. The first part of this review describes the production and processing of 94mTc. The second part covers basic concepts of technetium coordination chemistry with a special focus on the synthesis of 94mTc-labeled compounds for molecular imagin Read More

The unstable isotopes of chlorine have a brief history limited largely to production from sulphur isotopes. Recent improvements in accelerator targetry have made radiochlorine available from small cyclotrons, and concurrent research into labeling chemistry suggests both electrophilic and nucleophilic avenues for the synthesis of novel imaging probes. The prevalence of chlorine compounds from anthropogenic and natural Read More

Copper has five radioisotopes (60Cu, 61Cu, 62Cu, 64Cu, and 67Cu) that can be used in copper radiopharmaceuticals. These radioisotopes decay by mixed emissions of β+, β-, and γ with a wide range of half-lives from 9.74 min (62Cu) to 2.58 d (67Cu), which enable the design and synthesis of a variety of radiopharmaceuticals for different biomedical applications in diagnostic and therapeutic nuclear medicine. However, due to th Read More

Positron emission tomography (PET) has become a powerful tool for probing biochemical processes in living subjects. PET imaging depends largely on the development of novel PET tracers labeled with positron-emitting radionuclides. Since the four traditional PET isotopes (18F, 11C, 13N, and 15O) are produced in a cyclotron and are short-lived, their use for long-term observation of biological processes in vivo is limited. In the Read More

Positron emission tomography (PET) imaging with radiolabeled monoclonal antibodies has always been a dynamic area in molecular imaging. With decay half-life (3.3 d) well matched to the circulation half-lives of antibodies (usually on the order of days), 89Zr has been extensively studied over the last decade. This review article will give a brief overview on 89Zr isotope production, the radiochemistry generally used for 89Zr-lab Read More

New advances in nanotechnology has been responsible for the development of a new science called nanomedicine. In the recent years many discoveries as nanotubes and nanoparticles, especially for pharmaceuticals use, has increasing the application of nanotechnology for medical purposes. In this direction the development of nanoradiopharmaceuticals are also promising as novel radiopharmaceuticals. In this stud Read More

Background: More than 25% of 99mTc colloidal rhenium sulphide preparations have been reported to have a radiochemical purity of <95% in 11 radiopharmacies. Objectives: To identify the key parameters involved in radiochemical purity, different preparation procedures were analysed to develop an optimised preparation method. Methods: In the first part of this study, various data such as the Nanocis kit batch number, th Read More

Objective: The aim of the present study was to develop a 177Lu-labeled porphyrin derivative having favorable characteristics for use in targeted radiotherapy of cancer and to evaluate its biological behavior in mouse tumor models with respect to its effectiveness in tumor regression. Owing to the inherent affinity of porphyrins to accumulate in the tumors, suitably modified porphyrin derivative was chosen as the vehicle for t Read More

99mTc-macroaggregated albumin is widely used to diagnose pulmonary embolism. To control the radiochemical purity of this radiopharmaceutical, three rapid control methods using filter, thin layer chromatography or centrifugation, are described in the academic literature. In this paper, the interactions between impurities and 99mTc-macroaggregated albumin were presented. For each control method, the influence of these Read More

Purpose: The almost constant presence of apparent metabolic hypermetabolism of cerebellar vermis seen on 18FDG PET in a population of injured brains has been reported in a previous paper. Aim of this paper is to determine a) whether there is a correlation between the entity of this sign, semi quantitatively determined, and the severity of the trauma at its onset, and b) whether the entity of the relative enhancement corre Read More