Current Radiopharmaceuticals - Volume 3, Issue 4, 2010

Primary hyperparathyroidism (HPT) occurs in approximately 42 out of every 100,000 individuals, with women affected nearly three times more than men. It is predominantly caused by a single parathyroid adenoma, but can also be caused by glandular hyperplasia, and carcinoma. Definitive treatment for primary hyperparathyroidism remains surgical removal of affected glands, often a challenge due to the considerable anat Read More

Cyclo-(3-methylsaligenyl)-5-O-[1-(2,4-difluoro-5-[125I]iodophenyl)-2-deoxy-β-D-ribofuranosyl]phosphate (cycloSal- dRF[125I]IB) was radioiodinated with sodium [125I]iodide via copper-catalyzed isotope exchange in 48% radiochemical yield. cycloSal-dRF[125I]IB was found to be incorporated into the cytoplasmic nucleic acid and mitochondrial fractions of murine KBALB and K-STK (engineered to express HSV-1 thymidine kinase) ce Read More

Aim of the present review is to report the use of Positron Emission Tomography (PET) with [11C]- metahydroxyephedrine ([11C]mHED) in different clinical conditions, including heart failure, coronary artery disease, arrhythmogenic disorders, diabetes mellitus, idiopathic Parkinson's disease and adrenal tumors. [11C]mHED is a radio-labeled neurotransmitter PET tracer used to evaluate global and regional sympathetic presynapti Read More

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Hepatic arterial infusion chemotherapy (HAIC) is a palliative therapy option for advanced, unresectable liver metastases from colorectal carcinoma. A woman with multiple colorectal liver metastases was treated with HAIC and systemic chemotherapy. Serial 18F-FDG PET/CT imaging showed local therapeutic response of liver metastases to regional delivery of chemotherapy, but concurrent disease progression at extra-hepatic site Read More

Infarct avid radiopharmaceuticals are necessary for rapid and timely diagnosis of acute myocardial infarction. None of the infarct avid radiopharmaceuticals so far developed fulfill all the required criteria like rapid localization at the infarct, high avidity and specificity, and reasonable duration of scan positivity. 99mTc Cysteine was already reported from this laboratory as a suitable radiopharmaceutical to determine bo Read More

Purpose: Practically all solid malignant tumours have central hypoxia, which makes them less vulnerable to most forms of both radiotherapy and chemotherapy. Estramustine phosphate (EMP) is known to sensitise cancer cells and tumours to irradiation and to increase blood flow in malignant tumours. This study was designed to assess the effect of EMP and radiotherapy on the oxygenation status of the tumours. Methods and Read More

Nuclear Medicine and with it, the production of radiopharmaceuticals, represent an increasingly important part of the global medical market. This market is estimated at over $3 billion per year and growing. In this study, we compare the current Brazilian radiopharmaceuticals production and consumption with that of the USA and Europe. Brazil's market corresponds to 6.7% of the USA and Europe markets in terms of billing. W Read More

ErbB-2 is a type 1 receptor tyrosine kinase over-expressed on ~30% of breast cancers and is an attractive target for the development of new diagnostic and therapeutic agents. In this study, an ErbB-2-targeting peptide, KCCYSL, previously isolated using bacteriophage display, was radiolabeled with [99mTc(H2O)3(CO)3]+ and examined for breast cancer in vitro cell binding and in vivo biodistribution and breast cance Read More

Third generation self-inactivating lentiviral vectors (LV) are highly efficient, achieving long-term expression of the transgene in several target tissues. In order to induce iodide and astatide uptake for radionuclide therapy, we employed LV co-expressing the sodium/iodide symporter (NIS) and GFP to transduce glioma cells (DBTRG). LV transduction was compared with transient or stably transfected cells. NIS-cDNA (2023bp) Read More