Current Radiopharmaceuticals - Volume 3, Issue 2, 2010

Nowadays it is becoming increasingly commonplace for a physician to prescribe an FDG-PET scan, especially in oncology. FDG, short for 2-[18F]fluoro-2-deoxy-D-glucose, is a radioactive derivative of D-glucose that accumulates in tissue according to their degree of D-glucose utilization and is therefore very suitable to detect tumours and evaluate their metabolic state. The radiosynthesis of FDG was achieved for the first Read More

Fluorine-18 is the most important radionuclide used in positron emission tomography (PET) today, largely due to its attractive physical and nuclear characteristics. Agents such as the clinical oncology tracer 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG), the most widely used PET-radiopharmaceutical, are driving an increasing interest in the chemistry of radiopharmaceuticals utilizing fluorine-18. This review outline Read More

In this review we are looking at some aspects of nucleophilic aliphatic radiofluorination, notably the labelled fluoride source, design aspects, the leaving group and the solvent. It should be clear that there is more to this branch of radiolabelling than one would suspect from the frequently used standard tosylate replacement with kryptofix/[18F]fluoride in acetonitrile or DMSO. Competitive elimination can be a serious problem tha Read More

This review summarizes the possibilities of nucleophilic 18F-fluorination of complex molecules in activated carbocyclic aromatic position.

This review summarizes the possibilities of built-up syntheses of no-carrier-added radiofluorinated aromatic tracers via [18F]fluorobenzene derivatives as intermediate compounds.