Current Psychopharmacology - Volume 4, Issue 2, 2015

Background: The term Treatment- Resistant Depression is frequently used to describe patients that show poor response to conventional antidepressant therapy. Therefore a search for better and more efficacious treatment options is needed. The dopaminergic hypothesis for depression has been an attractive topic according to the growing evidence from basic research and clinical trials that have suggested th Read More

Background: Bipolar Disorder is a psychiatric condition highly disabling, with elevated rates of psychiatric and medical comorbidities that contribute substantially to morbidity and mortality. Pathophysiology of the illness is not well known but recent biologic and pharmacological studies suggest that altered receptor-mediated signal transduction mechanisms contribute to the pathophysiology of the disease. Accordingly, medicati Read More

Background: Bipolar Disorder is a severe psychiatric condition, characterized by depressive and manic mood states. Depressive mood remains a problem for most patients, as this is the predominant mood state, and because the options we have for treating depression remain scarce. Therefore, the quest for new treatment options is ongoing. Objective: We focus here on one approach in particular, regarding the know Read More

Background: Lithium has been considered the "gold standard" in the management of bipolar disorder, being the agent compared with "new mood stabilizer". It has also shown effect in the reduction of suicidal thoughts. Among the known mechanisms of action of lithium it has been described the inhibition in inositol monophosphatase (IMP) as resulting in non-competitive inhibition of IMP, resulting in a decrease of inositol in the Read More

Background: Both Bipolar Disorder (BD) and Obsessive Compulsive Disorder (OCD) are chronic psychiatric conditions, the first characterized by depressive and manic mood episodes and the latter characterized by obsessions and compulsions. The comorbidity between BD and OCD is not rare, and the presence of both conditions conveys important complications. The treatment supposes a challenge since antidepressants, Read More

Background: Pharmacological management of geriatric patients in acute settings is complex due to the presence of medical comorbidities, risk of drug-drug interactions, and potential patient sensitivity to side effects. Objectives: This article will review the basic pharmacologic principles of management of older adults in acute settings. Method: The aforementioned principles will be described and illustrated with two clinical e Read More

For clinical management of psychosis, both classical and novel antipsychotic drugs are available, but teratogenic potential of second generation antipsychotic drugs in general and third generation in particular has not been established so far in clinical and preclinical studies. Reports on third generation antipsychotic drugs are not available. Therefore, present study has been undertaken to compare the teratogenic potential, a Read More

Background: High fats in diet are often considered as a root cause for metabolic alterations which turns to lead obesity, a serious health problem in developed countries.. Obesity is characterized as abnormal storage of fats in adipose tissue, which appear as a bodyweight beyond to the limit. It negatively affects diverse aspects of health and strongly correlated with other complications like diabetes type 2 and heart diseases. Obj Read More