Current Psychopharmacology - Volume 4, Issue 1, 2015

Background: The side effects of psychotropic drugs are commonly encountered in clinical practice. Sexual side effects of psychotropic drugs may affect compliance to the treatment if not properly treated. Different classes of psychotropic drugs are known to cause clinically significant sexual dysfunction. Objective: In this review, authors have attempted to briefly describe the common side effects of psychotropic agents and th Read More

Objective: To investigate clinical response rates of Deep Brain Stimulation (DBS) as an intervention for treatment resident depression (TRD). Method: We performed a Pubmed search using the search terms deep brain stimulation, treatment resistant depression, DBS and TRD which resulted in three-hundred and seventythree records. Eighty-four articles were screened and duplicates were removed. Inclusion criteria Read More

Objectives: This prospective, open-label study investigated the effectiveness of Quetiapine Extended-Release (XR) in the treatment of Bipolar II Depressive Episode and its impact on quality of life in postpartum, non-lactating women. Method: Of the twenty-six women enrolled, fifteen completed the fourteen week study. Quetiapine XR was initiated at 50 mg and titrated up to 300 mg daily. Rating scales: Hamilton and M Read More

Background: comorbidity with cardiovascular disorders and metabolic syndrome influences QTc elongation in psychiatric sufferers, rather than antipsychotic treatment. Female gender and advanced age predict QTc elongation in psychiatric patients, while some studies questioned the impact of antipsychotic treatment. Objective: we hypothesized that female gender, advanced age, metabolic syndrome, smoking, somatic and Read More

Background: Negative symptoms are categorized by some of the scholars into ‘primary vs secondary ‘, ‘enduring vs transitory ‘and ‘treatment-resistant vs treatmentresponsive’ groups. But it seems that such kind of grouping may not be practically supportable. Objective: Exploring the genuineness of the abovementioned grouping and reports regarding resistance of negative symptoms against current treatments. Meth Read More

Introduction: Some studies have shown that more than 40% of patients with first episode psychosis (FEP) are non - adherent and treatment with long - acting antipsychotics (LAIs) may increase their compliance. However, studies on efficacy of LAIs versus oral antipsychotics for preventing relapse among schizophrenia patients have produced conflicting results. Objectives: The aim of the present study is to assess in naturali Read More

Background: A number of studies in rodents suggest that antipsychotic drug treatment can either alter the levels or functionality of the N-methyl-D-aspartate receptor (NMDAR). This raises the possibility that some of the therapeutic actions or side-effects of antipsychotic drugs could be mediated through the NMDAR. Objective: To determine if treatments with combinations of psychotropic drugs change the levels of the N Read More