High Fat Diet-Induced Obesity Stimulate Depressive Behavior in Rats

Background: High fats in diet are often considered as a root cause for metabolic alterations which turns to lead obesity, a serious health problem in developed countries.. Obesity is characterized as abnormal storage of fats in adipose tissue, which appear as a bodyweight beyond to the limit. It negatively affects diverse aspects of health and strongly correlated with other complications like diabetes type 2 and heart diseases. Objective: The study aimed to evaluate the manifestations of high fat diet on physiological changes undergoing in the body and their association in developing obesity. Method: Study conducted on male wistar rats, treated with high fats for 5 weeks to produce the animal model of obesity. Food intake, Body weight, activity in familiar (home cage) and novel (open field) environment were monitored once per week which was shown disturbed in animal model of obesity. Results: The consumption of fats causes disturbance in food intake and appeared as positively associated with body weight gain and obesity. Locomotor activity was found significantly decreased in animals consuming fat rich diet as it was expected. Fat diet also produced anxiogenic behavior in animals as the time spent in light box was decreased with the long term treatment. Conclusion: This pre clinical trial suggests that the diet with strong fat profile can be a big promoter of adiposity with different health hazards.