Current Psychiatry Research and Reviews - Current Issue
Volume 21, Issue 2, 2025
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Paradigms and Practice Shifts: A Topical Narrative Review of the Evolving Face of Exposure-Based Treatment for Youth
Authors: Robert D. Friedberg, Megan Neelley, Tia Lee, Runze Chen, Isabella Xie, Joee Zucker and Alanna GreenbergerExposure therapy is the gold standard treatment for anxiety and obsessive-compulsive disorders in children, adolescents, and adults. Inhibitory Learning Theory offers a nuanced and advanced perspective on exposure treatment positing that violating threat expectancies is more important than habituation. This paper highlights the effectiveness of inhibitory learning theory-guided exposure procedures for youth with anxiety and OCD, chronic pain, and eating disorders. A topical review focusing on the theoretical foundations of inhibitory learning theory, crucial augmentations of the approach, and outcomes with pediatric patients diagnosed with anxiety, eating, and pain disorders is presented. The literature review indicated that inhibitory learning theory-driven exposure produced beneficent outcomes in the identified populations. Various limitations and future directions were discussed. Limitations notwithstanding, inhibitory learning theory-led exposure represents a viable treatment option for pediatric patients with anxiety, eating, and chronic pain disorders.
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Cognitive Rehabilitation For Early-Stage Dementia: A Review
In the primary phases of Alzheimer's disease (AD) and vascular dementia, memory impairments and cognitive abnormalities are common. Because of the rising prevalence of dementia among the elderly, it is critical to promote healthy habits that can delay the onset of cognitive decline. Cognitive training (CT) and cognitive rehabilitation (CR) are particular treatments aimed to resolve memory and further areas of cognitive working in order to overcome these challenges. These are some of the different kinds of non-pharmacological treatments like reality orientation and skills training programs that can be used to deal with the cognitive and non-cognitive repercussions. The purpose of this review is to assess the efficacy and influence of cognitive training and cognitive rehabilitation in patients who are in their early phases of Alzheimer's disease or vascular dementia. These interventions are geared toward improving the patients' memory, in addition to other aspects of their cognitive functioning.
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Cross-talk between Peptide Neurotransmitters and their Role in Homeostasis of Brain, Behavior, and Immunity
Authors: Soni Rani, Shubham Yadav and Soma Mondal GhoraiThe bidirectional communication among the different peptide neurotransmitters and their receptors influences brain, immunity, and behavior. Among the peptide neurotransmitters, Glutamate is the primary excitatory while; gamma-aminobutyrate (γ-GABA), is the inhibitory neurotransmitter. Glutamatergic/GABAergic imbalances are seen in many neurological and autoimmune disorders. With an aim to understand more deeply the intricacies of glutamate/GABA homeostasis, we provide a critical review of glutamate, glycine and GABA peptide neurotransmitters and their role in the brain, behavior, and immunity. Another aspect of maintaining this homeostasis has its origin in the gut-brain-axis which influences mood and behavior via the bidirectional biochemical exchange network between central (CNS) and enteric nervous system (ENS). This present review also provides evidence of the cross-talk between glutamate, glycine, and GABA along the microbiota-gut-brain axis, thus any variations in this axis bear the consequences of the pathological condition. Drugs like alcohol, Benzodiazepines (Barbiturates) and neurosteroids inhibit the excitatory action of glutamate leading to an overall increase of glutamate/GABA ratio that causes relaxation of nerves. However, these drugs are misused and abused among drug addicts and now their commercial production is either banned or downsized and heavily monitored. Because only a limited number of drug molecules are considered in pharmaceutics and clinics as antidepressants, it is essential to focus on alternate peptide modulator analogues which are safe, eco-friendly and can be used as drugs to relieve stress and anxiety. In this review, we present a synopsis of the studies on synthetic GABAergic agonists or GABA modulators that can be targeted for future therapeutics and clinics.
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Factors Affecting Psychological Health in the COVID-19 Pandemic
Authors: Sherien Santosha, Vatsalya Tiwari, Sharad Chand, Manoj S. Dikkatwar, Supriya Roy and Radhika BinduGlobal mental health has been put at risk by the coronavirus disease 2019 (COVID-19) pandemic, both directly and indirectly through disruptive social shifts and neuropsychiatric repercussions of SARS-CoV-2 infection. Despite a little rise in self-reported mental health issues, there has not been an increase in the population's rates of mental disorders, self-harm, or suicide that could be measured objectively. Demographic factors, such as sex, age, and profession, have emerged as key determinants, with women, younger individuals, and frontline workers facing elevated risks. In this review, we have addressed the key considerations that have impacted the mental well-being of the populace during COVID-19. A comprehensive literature search on the SCOPUS and PubMed databases was used to find the current research studies on the COVID-19 outbreak relevant to mental health. According to preliminary research, self-reported stress (8%) and symptoms of worry and depression (16–28%) have been prevalent psychological responses to the COVID-19 pandemic and they may have been linked to sleep disruption. This risk has been reported to be moderated by several individual and systemic factors. Acute and post-acute neuropsychiatric consequences of COVID-19 have also been identified, with a significant prevalence of fatigue, cognitive decline, and anxiety and depression symptoms, even months after infection. Coping with challenges, such as social distancing, economic instability, and altered routines, has posed significant mental health concerns. Access to mental health resources and robust social support systems has, however, played pivotal roles in addressing these challenges. The review has underscored the urgent need for comprehensive mental health interventions, addressing social determinants, ensuring equitable access to healthcare, and recognizing the enduring effects of the pandemic.
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The Experience of Parents When they Find Out that their Child has Autism: A Phenomenological Study
Authors: Shirdel Zandi, Ensiyeh Jenabi, Saeed Bashirian, Reza Mohammadi, Fatemeh Karbin and Salman KhazaeiBackgroundMothers, as vital and important individuals in their children's lives, experience various struggles, emotions, and experiences in relation to their child's autism diagnosis. This study aims to provide an in-depth understanding of mothers' experiences in dealing with the diagnosis of autism in their child using a phenomenological approach.
MethodsIn this study, a qualitative phenomenological approach was used, and purposeful sampling was employed until data saturation was achieved. The participants were selected from mothers who sought their children's participation in rehabilitation classes at the Autism Spectrum Disorder Research Center in Hamedan, Iran. Unstructured interviews were conducted as the method of data collection. The descriptive method of Colaizzi was utilized for analyzing the obtained data.
ResultsTwelve participants took part in this study. The average age of the participants was 35.16 years. The analysis of mothers' lived experiences in dealing with their child's autism diagnosis using a descriptive phenomenological approach revealed four main themes: fear of the child's future, worry about social harassment, emergence of emotional shock, and fear of trouble.
ConclusionThe results of this study demonstrated that concern for the child's future, worry about social harm, experiencing emotional shock, and fear of being trapped were the major challenges faced by mothers upon learning about their child's positive autism diagnosis. Therefore, professionals, policymakers, and regulatory organizations should pay attention to the issues raised in parents' experiences in order to provide appropriate healthcare services for children with autism and their families.
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Differentiation of Restless Genital Syndrome from Persistent Genital Arousal Disorder: A Case Report
Authors: Mandana Haghshenas and Elham Moein PoorObjectivePersistent genital arousal disorder (PGAD) presents with a constant unwelcome sensation of genital arousal. Moreover, restless genital syndrome (RGS) is one of the restless leg syndrome (RLS) variants.
Case RepresentationWe aimed to clarify the differences between clinical diagnoses of these two similar conditions. Assessing the circadian pattern of symptoms, the simultaneous presence of RLS and restless bladder syndrome, exacerbation of symptoms with caffeine use, healing with magnesium use, and familial history of RLS helped us with the differentiation between PGAD and RGS.
ConclusionWe propose to rule out the diagnosis of RGS in all patients with PGAD symptoms.
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Investigating the Effect of Ginger as an Adjunctive Treatment along with SSRIs to Reduce Anxiety in Patients with GAD: A Clinical Trial Study
Authors: Sara Ataei, Leila Jahangard, Sina Anaraki, Dara Dastan and Salman KhazaeiIntroductionGeneralized anxiety disorder (GAD) is characterized by exaggerated anxiety without any apparent cause of concern. The primary treatment of this disorder is usually SSRIs, which have many digestive side effects and do not provide complete treatment for the patient. The use of non-pharmacological methods may help reduce these complications. Therefore, the present study was conducted to investigate the effect of ginger as an adjunctive therapy along with SSRIs to reduce anxiety in patients with GAD.
Materials and MethodsIn this double-blind, controlled clinical trial study, a total of 80 patients with GAD were randomly assigned into two groups. For the intervention group, at the same time as SSRI drug, two 500-mg ginger capsules were used daily while in the control group, two starch capsules were used daily as a placebo along with SSRI. Data collection tools were Hamilton's anxiety questionnaire and a gastrointestinal symptom severity scale. Data were collected before the intervention and after the 12-week intervention.
ResultsThere was no significant difference between the intervention and control groups in terms of average anxiety and severity of digestive symptoms before the intervention (p > 0.05), but there was a significant difference between the groups after the intervention (p < 0.05). Also, the average scores of anxiety and severity of gastrointestinal symptoms in the intervention group increased significantly from the beginning of the intervention to the follow-up (intragroup difference) (p < 0.05).
ConclusionThe results of the study showed that the use of ginger along with SSRIs reduced anxiety and released the severity of gastrointestinal symptoms in patients with GAD. In addition, in this study, it was found that ginger, along with SSRIs, can have beneficial effects on indigestion, diarrhea, and nausea in patients with GAD. However, these findings require more extensive research.
Clinical Trial Registration No.IRCT20201108049306N1.
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The Psychological Status of Healthcare Workers of a COVID-19-Free Cancer Hospital during COVID-19 Pandemic in Turkey - A Cross-sectional Study
BackgroundIdentifying the psychosocial effects on healthcare workers is critical in dealing with the COVID-19 pandemic.
ObjectiveIn this study, we aimed to examine the psychological effects of the COVID-19 pandemic on healthcare workers of a cancer hospital in Turkey and to determine its predictors.
MethodsThe psychosocial effects of the epidemic on hospital staff were evaluated by a psychiatrist through a face-to-face psychiatric interview. A semi-structured questionnaire containing socio-demographic variables and questions about social changes, and Symptom Checklist-90 Revised (SCL-90-R) were administered to the hospital staff that agreed to participate in the study.
ResultsTwenty-three percent of the subjects had threshold values for the Global Severity Index in SCL-90-R. The most common symptoms were obsessions and depressive symptoms (42% and 36.5%, respectively). Being young, being a woman, being single, worsening economic situation, high education level, history of past psychiatric disorders, isolation and/or quarantine history, lack of personal protective equipment, separation from the family, fear of infecting a family member or cancer patient were determined as risk factors.
ConclusionThe COVID-19 pandemic has resulted in significant psychosocial impact on healthcare workers, highlighting the need for appropriate strategies to understand and mitigate these effects.
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The Association Between Internalized Stigma and Feelings of Loneliness and Quality of Life in Patients with Mental Disorders
Authors: Mohammad Akhoondi, Efat Sadeghian, Erfan Aubi and Farshid ShamsaeiBackgroundIndividuals with mental disorders are subject to stigma from society. Some patients accept and internalize this stigma, while others suffer from loneliness and reduced quality of life.
ObjectiveThis study aimed to investigate the relationship between internalized stigma, feelings of loneliness, and quality of life in patients with mental disorders.
MethodsIn 2023, a descriptive study was conducted on 250 patients with psychological disorders who were referred to Sina Hospital (Farshchian) in Hamadan. The patients were selected using a convenience sampling method. Data were collected through face-to-face interviews using four questionnaires: demographic information, the internalized stigma of mental illness, Russell's loneliness scale, and the World Health Organization's 26-item quality of life questionnaire. The data were analyzed using descriptive and inferential statistical tests in SPSS-22 software.
ResultsThere was a significant positive correlation between internal stigma and loneliness (p < 0.001, r = 0.817) and a significant negative correlation between internal stigma and quality of life (p < 0.001, r = -0.777). Additionally, loneliness and quality of life had a significant negative correlation (p < 0.001, r = -0.838).
ConclusionThe results generally indicate that approximately half of the patients with internalized stigma experience moderate to severe distress. As internalized stigma increases, patients are more likely to experience feelings of loneliness and decrease their quality of life. Therefore, it is recommended that measures be taken to reduce internalized stigma in patients with psychiatric disorders to alleviate feelings of loneliness and improve their quality of life.
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