Current Protein and Peptide Science - Volume 22, Issue 3, 2021

Drug reposition, or repurposing, has become a promising strategy in therapeutics due to its advantages in several aspects of drug therapy. General drug development is expensive and can take more than 10 years to go through the designing, development, and necessary approval steps. However, established drugs have already overcome these steps and thus a potential candidate may be already available decreasing the Read More

Anticancer peptides (ACPs) eliminate pathogenic bacteria and kill tumor cells, showing no hemolysis and no damages to normal human cells. This unique ability explores the possibility of ACPs as therapeutic delivery and its potential applications in clinical therapy. Identifying ACPs is one of the most fundamental and central problems in new antitumor drug research. During the past decades, a number of machine learning-base Read More

Antimicrobial peptides (AMPs) are natural polypeptides with antimicrobial activities and are found in most organisms. AMPs are evolutionarily conservative components that belong to the innate immune system and show potent activity against bacteria, fungi, viruses and in some cases display antitumor activity. Thus, AMPs are major candidates in the development of new antibacterial reagents. In the last few decades, A Read More

Flavonoids are plant products abundant in every day diets and are claimed to be beneficial for the human health. After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through the formation of flavonoids-SA complex. This review deals with the current state of knowledge on the flavonoids-SA complex forthe past 10 years, mainly involving multi-spectroscopic techn Read More

Angina pectoris, associated with coronary artery disease, a cardiovascular disease where the pain is caused by adverse oxygen supply in the myocardium, results in contractility and discomfort in the chest. Inflammasomes, triggered by stimuli due to infection and cellular stress, have been identified to play a vital role in the progression of cardiovascular disorders and, thus, causing various symptoms like angina pectoris. Nlr Read More

Traditional network-based computational methods have shown good results in drug analysis and prediction. However, these methods are time-consuming and lack universality, and it is difficult to exploit the auxiliary information of nodes and edges. Network embedding provides a promising way for alleviating the above problems by transforming the network into a low-dimensional space while preserving network structure an Read More

Drug Repurposing (DR) is an alternative to the traditional drug discovery process. It is cost and time effective,with high returns and low-risk process that can tackle the increasing need for interventions for varied diseases and new outbreaks. Repurposing of old drugs for other diseases has gained wider attention, as there have been several old drugs approved by the FDA for new diseases. In the global emergency of COVID-19 pan Read More